Increased Network Excitability Due to Altered Synaptic Inputs to Neocortical Layer V Intact and Axotomized Pyramidal Neurons after Mild Traumatic Brain Injury

Journal of Neurotrauma
Anders HånellKimberle M Jacobs

Abstract

Mild traumatic brain injury (mTBI) can produce long lasting cognitive dysfunction. There is typically no cell death and only diffuse structural injury after mTBI. Thus, functional changes in intact neurons may contribute to symptoms. We have previously shown altered intrinsic properties of axotomized and intact neurons within 2 d after a central fluid percussion injury in mice expressing yellow fluorescent protein (YFP) that allow identification of axonal state prior to recording. Here, whole-cell patch clamp recordings were used to examine synaptic properties of YFP(+) layer V pyramidal neurons. An increased frequency of spontaneous and miniature excitatory postsynaptic currents (EPSCs) was recorded from axotomized neurons at 1 d and intact neurons at 2 d after injury, likely reflecting an increased number of afferents. This also was reflected in the increased amplitude of the EPSC evoked by local extracellular stimulation for all neurons from injured cortex and increased likelihood of producing an action potential for intact cells. Field potentials recorded in superficial layers after online deep layer stimulation contained a single negative peak in controls but multiple negative peaks in injured tissue. The amplitude of this...Continue Reading

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Citations

May 3, 2016·Neurosurgical Focus·Sarah K B Bick, Emad N Eskandar
Mar 17, 2017·Journal of Neurotrauma·John A WolfD Kacy Cullen
Sep 27, 2018·Cognitive Neurodynamics·Yingmei QinJia Zhao
Oct 13, 2020·The Journal of Clinical Investigation·Punam A Sawant-PokamK C Brennan
Aug 27, 2021·Neuroscience and Biobehavioral Reviews·Matthieu FaillotSuhan Senova

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