Increased neural sensitivity to self-relevant stimuli in major depressive disorder

Psychophysiology
Erik M BenauDan Foti

Abstract

The current research examined how individuals with depression process emotional, self-relevant stimuli. Across two studies, individuals with depression and healthy controls read stimuli that varied in self-relevance while EEG data were recorded. We examined the late positive potential (LPP), an ERP component that captures the dynamic allocation of attention to motivationally salient stimuli. In Study 1, participants read single words in a passive-viewing task. Participants viewed negative, positive, or neutral words that were either normative or self-generated. Exploratory analyses indicated that participants with depression exhibited affective modulation of the LPP for self-generated stimuli only (both positive and negative) and not for normative stimuli; healthy controls exhibited similar affective modulation of the LPP for both self-relevant and normative stimuli. In Study 2, using a separate sample and a different task, stimuli were provided within the context of sentence stems referring to the self or other people. Participants with depression were more likely to endorse negative self-referent sentences and reject positive ones compared to healthy controls. Depressed participants also exhibited an increased LPP to negative...Continue Reading

References

Apr 1, 1983·Electroencephalography and Clinical Neurophysiology·G GrattonE Donchin
Mar 1, 1994·Journal of Behavior Therapy and Experimental Psychiatry·M M Bradley, P J Lang
May 19, 2001·Journal of Abnormal Psychology·P J DeldinJ L Best
Jun 26, 2002·Psychological Bulletin·Nilly Mor, Jennifer Winquist
May 4, 2005·Biological Psychiatry·Avgusta Y ShestyukChristen M Deveney
Dec 15, 2005·Journal of Abnormal Psychology·Jonathan RottenbergIan H Gotlib
Oct 4, 2006·Progress in Brain Research·Harald T SchuppMarkus Junghöfer
Oct 4, 2006·Progress in Brain Research·Johanna KisslerCornelia Herbert
Mar 21, 2007·Behaviour Research and Therapy·Ed WatkinsYanni Malliaris
Mar 30, 2007·Brain Research·Philipp Kanske, Sonja A Kotz
Nov 17, 2007·Clinical Psychology Review·Lauren M BylsmaJonathan Rottenberg
Jan 29, 2008·Psychophysiology·Cornelia HerbertJohanna Kissler
Jan 23, 2009·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Greg HajcakDan Foti
Feb 14, 2009·Laterality·Keith M YoungPaul Atchley
Jun 2, 2009·Biological Psychology·Jason W Krompinger, Robert F Simons
Sep 15, 2009·Biological Psychiatry·Thomas SuslowUdo Dannlowski
Apr 3, 2010·The American Journal of Psychiatry·Avgusta Y Shestyuk, Patricia J Deldin
Apr 15, 2010·Developmental Neuropsychology·Greg HajcakDoreen M Olvet
Jun 26, 2010·Depression and Anxiety·Dan FotiGreg Hajcak
Sep 3, 2010·Annual Review of Psychology·Marta Kutas, Kara D Federmeier
Sep 22, 2010·International Journal of Psychophysiology : Official Journal of the International Organization of Psychophysiology·Mareike BayerAnnekathrin Schacht
Sep 22, 2010·Social Cognitive and Affective Neuroscience·Cornelia HerbertBeate M Herbert
Nov 26, 2010·Social Neuroscience·Cornelia HerbertPaul Pauli
Jan 28, 2011·Journal of Cognitive Neuroscience·Anna Weinberg, Greg Hajcak
Feb 16, 2011·Journal of Abnormal Psychology·Lauren M BylsmaJonathan Rottenberg
Jul 23, 2011·The British Journal of Psychiatry : the Journal of Mental Science·Edward R WatkinsJan Scott
Mar 8, 2012·Behavior Research Methods·Marc BrysbaertEmmanuel Keuleers
May 16, 2012·NeuroImage·Eric C Fields, Gina R Kuperberg
Jun 2, 2012·Cognition & Emotion·Ruth Ann AtchleyRebecca J Lepping
Sep 14, 2012·Frontiers in Integrative Neuroscience·Eddie Harmon-JonesTom F Price
Sep 18, 2012·Neuropsychologia·Manuel Martín-LoechesSabela Fondevila
Feb 14, 2013·Behavior Research Methods·Amy Beth WarrinerMarc Brysbaert

❮ Previous
Next ❯

Citations

Jan 31, 2020·Neuroscience and Biobehavioral Reviews·Paul FrewenGeorg Northoff
Jul 16, 2020·Journal of Affective Disorders·F A DuyserJ N Vrijsen
Jun 15, 2021·Journal of Psycholinguistic Research·Lora I DimitrovaAntje A T S Reinders
Jul 18, 2021·Cognitive, Affective & Behavioral Neuroscience·Lindsay DickeyAutumn Kujawa

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.