Increased neurocognitive intra-individual variability is associated with declines in medication adherence in HIV-infected adults

Neuropsychology
Nicholas S ThalerCharlie H Hinkin

Abstract

There is cross-sectional evidence that neurocognitive intra-individual variability (IIV), or dispersion, is elevated in human immunodeficiency virus (HIV) disease and is associated with declines in activities of daily living, including medication adherence. This longitudinal study extends this literature by examining whether increased neurocognitive IIV in HIV-positive persons over time predicts declines in medication adherence above and beyond changes in mean level of performance over a 6-month observation. After controlling for drug use, declines in mean performance, and changes in depressive symptoms, results confirmed that increases in IIV were associated with overall poorer antiretroviral medication adherence. HIV-positive individuals with the greatest increases in dispersion demonstrated marked reductions in adherence by the third month that exceeded what was observed in less variable individuals. Our results indicate that increases in dispersion are associated with poorer declines in medication adherence in HIV disease, which may have implications for the early detection and remediation of suboptimal antiretroviral adherence.

Citations

Aug 26, 2015·Brain Imaging and Behavior·Lindsay J HinesUNKNOWN Multicenter AIDS Cohort Study
Sep 6, 2017·PloS One·Nadia CorréardUNKNOWN FACE-BD collaborators
Mar 23, 2017·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Andrew J LevineUNKNOWN Multicenter AIDS Cohort Study-Neuropsychology Working Group
Aug 21, 2018·Journal of Clinical and Experimental Neuropsychology·Andrew J LevineUNKNOWN Multicenter AIDS Cohort Study–Neuropsychology Working Group
Jan 21, 2019·Current HIV/AIDS Reports·Leah H Rubin, Pauline M Maki
Apr 7, 2018·Frontiers in Aging Neuroscience·Natalie M Zahr
Jan 16, 2021·The Journal of the Association of Nurses in AIDS Care : JANAC·Drenna WaldropDavid E Vance
Aug 22, 2021·Archives of Clinical Neuropsychology : the Official Journal of the National Academy of Neuropsychologists·Anna J DreyerKevin G F Thomas
Nov 27, 2021·Neuropsychology Review·David E VancePariya L Fazeli

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