PMID: 8592271Nov 1, 1995Paper

Increased neuronal excitability conferred by a mutation in the Drosophila bemused gene

Journal of Neurogenetics
M SternK Walters

Abstract

We have identified a new gene in Drosophila on the basis of a mutation that affects both behavior and neuronal excitability. This mutation, called bemused (bem) is the result of a P element insertion at cytological position 85D. Flies defective at bem display greatly reduced coordination, flight ability and fertility. The bem mutation also affects synaptic transmission at the larval neuromuscular junction. In particular, bem larvae display a more rapid onset of augmentation than bem+ larvae. This effect is potentiated by the potassium channel blocking drug quinidine. The increased transmitter release that occurs in bem mutants following repetitive nerve stimulation is accompanied by the appearance of extra action potentials in the motor neuron. We conclude that the bem mutation increases neuronal excitability, possibly as a result of a defect in an ion channel structural or regulatory gene.

References

Jul 28, 1977·Proceedings of the Royal Society of London. Series B, Containing Papers of a Biological Character·Y N JanM J Dennis
Jan 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·Y N Jan, L Y Jan
Feb 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·R GangulyR Krishnan
Jan 1, 1992·Annual Review of Physiology·U B Kaupp, K W Koch
Nov 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·T ElkinsC F Wu
Aug 1, 1989·Journal of Neurogenetics·M Stern, B Ganetzky
Jan 31, 1967·Proceedings of the Royal Society of London. Series B, Containing Papers of a Biological Character·B Katz, R Miledi
Sep 1, 1967·The Journal of Physiology·B Katz, R Miledi
Feb 1, 1971·Proceedings of the National Academy of Sciences of the United States of America·Y Hiraizumi
Feb 1, 1969·Genetics·W D Kaplan, W E Trout
Jun 1, 1994·Neuron·L L IsomW A Catterall
Mar 1, 1994·Current Biology : CB·S A Siegelbaum
Aug 11, 1994·Nature·M L AshfordJ P Adelman
May 1, 1994·Pflügers Archiv : European journal of physiology·C PoulainA Mallart
Jun 17, 1994·Science·J C Hall
Jan 1, 1994·Annual Review of Neuroscience·D E Clapham

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Citations

Nov 12, 1996·Proceedings of the National Academy of Sciences of the United States of America·H SoehngeM Stern
Jul 13, 2012·Genes, Brain, and Behavior·C JohnsonM Stern
Dec 18, 2020·Neurobiology of Learning and Memory·Timothy E BlackCharles I Abramson
Feb 21, 2003·Current Biology : CB·Josh DubnauTim Tully

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