Increased neuronal signatures of targeted memory reactivation during slow-wave up states

Scientific Reports
Maurice GöldiThomas Schreiner

Abstract

It is assumed that slow oscillatory up-states represent crucial time windows for memory reactivation and consolidation during sleep. We tested this assumption by utilizing closed-loop targeted memory reactivation: Participants were re-exposed to prior learned foreign vocabulary during up- and down-states of slow oscillations. While presenting memory cues during slow oscillatory up-states improved recall performance, down-state cueing did not result in a clear behavioral benefit. Still, no robust behavioral benefit of up- as compared to down-state cueing was observable. At the electrophysiological level however, successful memory reactivation during up-states was associated with a characteristic power increase in the theta and sleep spindle band. No oscillatory changes were observable for down-state cues. Our findings provide experimental support for the assumption that slow oscillatory up-states may represent privileged time windows for memory reactivation, while the interplay of slow oscillations, theta and sleep spindle activity promotes successful memory consolidation during sleep.

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Citations

Dec 6, 2019·Physiological Reviews·Laura M J Fernandez, Anita Lüthi
Apr 7, 2020·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Arnaud Boutin, Julien Doyon
Sep 5, 2019·Frontiers in Neuroscience·Maya Geva-Sagiv, Yuval Nir
Oct 20, 2020·Frontiers in Neuroscience·Bryce A Mander
May 27, 2021·Nature Communications·Thomas SchreinerBernhard P Staresina
Jul 28, 2020·Current Opinion in Physiology·Chen Song, Enzo Tagliazucchi
Aug 18, 2021·Learning & Memory·Julia CarboneSusanne Diekelmann
Jul 8, 2021·Nature Communications·Virginie SterpenichSophie Schwartz

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