Increased Neutrophil/Lymphocyte Ratio in Patients with Depression is Correlated with the Severity of Depression and Cardiovascular Risk Factors

Psychiatry Investigation
Esra Aydin SunbulH Gulec

Abstract

Chronic inflammation is associated with cardiovascular (CV) risk factors and psychiatric disorders. The neutrophil to lymphocyte ratio (NLR) has been investigated as a new biomarker for systemic inflammatory response. The aim of the study is to investigate the relation of NLR with severity of depression and CV risk factors. The study population consisted of 256 patients with depressive disorder. Patients were evaluated with the Hamilton Rating Scale for Depression (HAM-D). Patients were classified into four groups according to their HAM-D score such as mild, moderate, severe, and very severe depression. Patients were also evaluated in terms of CV risk factors. Patients with higher HAM-D score had significantly higher NLR levels compared to patients with lower HAM-D score. Correlation analysis revealed that severity of depression was associated with NLR in depressive patients (r=0.333, p<0.001). Patients with one or more CV risk factors have significantly higher NLR levels. Correlation analysis revealed that CV risk factors were associated with NLR in depressive patients (r=0.132, p=0.034). In logistic regression analyses, NLR levels were an independent predictor of severe or very severe depression (odds ratio: 3.02, 95% confide...Continue Reading

References

Mar 13, 2001·Comprehensive Psychiatry·A AkdemirM H Ozbay
Jun 19, 2003·JAMA : the Journal of the American Medical Association·Ronald C KesslerUNKNOWN National Comorbidity Survey Replication
Feb 1, 1960·Journal of Neurology, Neurosurgery, and Psychiatry·M HAMILTON
Apr 22, 2005·The New England Journal of Medicine·Göran K Hansson
Aug 17, 2005·Current Drug Targets. Inflammation and Allergy·Tsuyoshi KasamaSteven L Kunkel
Aug 30, 2005·Journal of Affective Disorders·Aye-Mu MyintYong-Ku Kim
Jan 18, 2006·Lancet·Klaus P EbmeierJ Douglas Steele
Jul 26, 2006·Inhalation Toxicology·Carr J SmithJudy A King
Apr 17, 2007·Progress in Neuro-psychopharmacology & Biological Psychiatry·Yong-Ku KimJung-Bum Kim
Apr 24, 2007·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·K J HalazunJ P A Lodge
Sep 8, 2007·The Review of Diabetic Studies : RDS·Christos PitsavosChristodoulos Stefanadis
Jan 26, 2008·Circulation Journal : Official Journal of the Japanese Circulation Society·Mariusz KrukUNKNOWN ANIN Myocardial Infarction Registry Group
Sep 9, 2008·The American Journal of Cardiology·Umesh U TamhaneHitinder S Gurm
Jan 6, 2009·Current Opinion in Psychiatry·Timothy G Dinan
Mar 20, 2009·Psychosomatic Medicine·Marko ElovainioAntti Reunanen
Mar 4, 2011·Journal of Epidemiology·Seounghee LeeJoohon Sung
Jun 22, 2013·Clinical and Experimental Hypertension : CHE·Murat SunbulAltug Cincin
Sep 26, 2013·European Journal of Cardiovascular Nursing : Journal of the Working Group on Cardiovascular Nursing of the European Society of Cardiology·Rebecca L DekkerTerry A Lennie
Nov 5, 2013·Progress in Neuro-psychopharmacology & Biological Psychiatry·Aye-Mu Myint, Yong-Ku Kim
Nov 20, 2013·Biological Psychiatry·Marie Kim Wium-AndersenBørge Grønne Nordestgaard
Jul 17, 2014·Clinical Chemistry and Laboratory Medicine : CCLM·Cristina AndreoliEmanuela Corsini

❮ Previous
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Citations

Feb 27, 2019·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·Mario Gennaro MazzaMassimo Clerici
Jan 22, 2020·Clinical Psychopharmacology and Neuroscience : the Official Scientific Journal of the Korean College of Neuropsychopharmacology·Heather E SoderScott D Lane
Oct 17, 2020·Neuropsychiatric Disease and Treatment·Xiuqun GongMei Zhang
Feb 20, 2020·Peptides·Fengmei WeiYuhong Jing
Aug 22, 2018·Clinica Chimica Acta; International Journal of Clinical Chemistry·Huijun ChenJincai He
Jun 17, 2021·Psychiatry Investigation·Aybeniz Civan KahveYunus Hacimusalar
Jul 16, 2021·Neuroscience and Biobehavioral Reviews·Adam J WalkerMichael Berk
Jul 21, 2021·Journal of Basic and Clinical Physiology and Pharmacology·Oktay BulurMetin Uzman
Aug 27, 2021·Journal of Psychiatric Research·Vicent Llorca-BofíMaria Mur
Oct 26, 2021·Clinical Psychopharmacology and Neuroscience : the Official Scientific Journal of the Korean College of Neuropsychopharmacology·Serdar KaratoprakYunus Emre Dönmez
Sep 8, 2021·Asia-Pacific Journal of Public Health·Asnawi AbdullahMarthoenis Marthoenis
Dec 4, 2021·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Matteo WinkerJörg Faber
Dec 4, 2021·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·M Sanchez-AutetM P García-Portilla
Dec 18, 2021·Frontiers in Aging Neuroscience·Jaime Ramos-CejudoRicardo S Osorio

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