PMID: 9159616May 1, 1997Paper

Increased nitric oxide levels in exhaled air of rat lung allografts

The Journal of Thoracic and Cardiovascular Surgery
T MizutaH Matsuda

Abstract

In organ transplantation nitric oxide has been reported to be involved in allograft rejection. We examined in a rat lung transplantation model whether nitric oxide is overproduced in acute rejection and can be detected in exhaled air. Thirteen rat right lung transplants were separated into three groups: group 1 (n = 5), untreated allografts (Brown-Norway [RT1n] to Lewis [RT1l]); group 2 (n = 4), cyclosporine-treated allografts; and group 3 (n = 4), isografts (Lewis to Lewis). We examined exhaled nitric oxide levels with a chemiluminescence analyzer and chest roentgenograms on days 2 through 5. Histologic samples were obtained on days 3 and 5. On day 5, the recipients were killed and we measured exhaled nitric oxide from the right and left lungs separately. Blood samples were also obtained for measurement of serum nitrite/nitrate. The exhaled nitric oxide level in untreated allografts increased significantly from day 5 (63.9 +/- 39.2 ppb, p = 0.0095) and was significantly higher than that in treated allografts (9.1 +/- 1.6 ppb) (p = 0.0085) and isografts (6.9 +/- 0.5 ppb) (p = 0.0068). The nitric oxide level in untreated allografts (826.5 +/- 416.1 ppb) was 75 times as high as that from the contralateral normal left lungs (11.2 ...Continue Reading

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Citations

Feb 2, 2000·The Annals of Thoracic Surgery·B N MoraG A Patterson
Dec 9, 2000·Transplant International : Official Journal of the European Society for Organ Transplantation·A JeppssonC G McGregor
Aug 26, 2014·The Journal of Surgical Research·Marcus da Matta AbreuFabio Biscegli Jatene
May 7, 2009·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Markus HirschburgerVeronika Grau
Apr 20, 2001·The Annals of Thoracic Surgery·H ItanoG A Patterson
Dec 10, 1999·Pulmonary Pharmacology & Therapeutics·M Bernareggi, G Cremona
Dec 29, 1999·The Journal of Thoracic and Cardiovascular Surgery·S J SwansonD J Sugarbaker
Sep 20, 2012·Journal of Breath Research·Nhât-Nam Le-DongAnh Tuan Dinh-Xuan

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