Increased nitric oxide synthase activity despite lack of response to endothelium-dependent vasodilators in postischemic acute renal failure in rats

The Journal of Clinical Investigation
J D CongerP Shultz

Abstract

Lack of response to endothelium-dependent vasodilators generally has been considered to be evidence for decreased nitric oxide synthase (NOS) activity and NO generation after ischemic or hypoxic injury to vital organs including the kidney. In this study, renal blood flow (RBF) responses to endothelium-dependent vasodilators acetylcholine and bradykinin and the endothelium-independent vasodilator prostacyclin, the nonselective NOS inhibitor L-NAME (without and with L-arginine), the inducible NOS inhibitor aminoguanidine, and the NO-donor sodium nitroprusside were examined in 1-wk norepinephrine-induced (NE) and sham-induced acute renal failure (ARF) rats. Compared with sham-ARF, there was no increase in RBF to intrarenal acetylcholine and bradykinin, but a comparable RBF increase to prostacyclin in NE-ARF kidneys. However, there was a significantly greater decline in RBF to intravenous L-NAME in NE- than sham-ARF rats (-65 +/- 8 vs. -37 +/- 5%, P < 0.001) which was completely blocked by prior L-arginine infusion. There was no change in RBF to the inducible NOS specific inhibitor aminoguanidine. Unlike sham-ARF, there was no increase in RBF to intrarenal sodium nitroprusside in NE-ARF. Immunohistochemistry and immunofluorescence ...Continue Reading

References

Mar 1, 1979·Circulation Research·W J Arendshorst
Nov 1, 1992·Hypertension·D H SigmonW H Beierwaltes
Nov 1, 1992·The Journal of Clinical Investigation·P J Shultz, L Raij
Nov 1, 1991·The American Journal of the Medical Sciences·W L Henrich
Jun 1, 1991·Kidney International·J D CongerW S Hammond
Jan 1, 1990·Life Sciences·Y ShiboutaK Nishikawa
Jul 5, 1990·The New England Journal of Medicine·J A PanzaS E Epstein
Jan 16, 1989·Biochemical and Biophysical Research Communications·R M Palmer, S Moncada
Jul 1, 1980·Circulation Research·S WallensteinJ L Fleiss
Dec 1, 1993·Stroke; a Journal of Cerebral Circulation·Z G ZhangU Förstermann
Nov 2, 1993·European Journal of Pharmacology·K HasanR G Tilton
Nov 1, 1993·British Journal of Pharmacology·M J GriffithsT W Evans
Jan 1, 1994·Digestive Diseases·M C Wolvekamp, R W de Bruin

❮ Previous
Next ❯

Citations

Dec 2, 2000·The American Journal of Medicine·K A Nath, S M Norby
Oct 21, 1999·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·R WenselF X Kleber
Jan 6, 1999·The British Journal of Surgery·S C WeightM L Nicholson
Aug 25, 1999·The British Journal of Surgery·S C WeightM L Nicholson
Sep 29, 1998·The European Journal of Neuroscience·D Levy, D W Zochodne
Feb 8, 2003·Antioxidants & Redox Signaling·José M Valdivielso, Roland C Blantz
Jun 24, 2004·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Michael S Goligorsky
Mar 21, 2002·Critical Care Medicine·Stanislao MorgeraHans-Hellmut Neumayer
May 1, 2002·Current Opinion in Pediatrics·Sharon Phillips Andreoli
Sep 18, 2002·Kidney International·Veronika MüllerAttila J Szabó
May 15, 1996·The Journal of Clinical Investigation·E NoiriM S Goligorsky
Jul 15, 1997·The Journal of Clinical Investigation·H M Siragy, R M Carey
Jun 26, 2010·BMC Anesthesiology·John W SimmonsSteven E Wolf
Aug 1, 2002·Pediatric Research·Stephen M BlackJeffrey R Fineman
May 20, 2008·Molecular Medicine·Matthieu LegrandCan Ince
Aug 28, 2014·Amino Acids·Ada PopoloStefania Marzocco
Aug 10, 2005·World Journal of Surgery·Juan C Garcia-PerezJose L Balibrea
May 1, 1997·Kidney International·C L EdelsteinR W Schrier
Feb 19, 2002·Kidney International·Michael S GoligorskyEisei Noiri
Jul 1, 1997·Kidney International·M NangakuR J Johnson
Dec 21, 2010·Nitric Oxide : Biology and Chemistry·Joelma Santina ChristoElisa Mieko Suemitsu Higa
Jul 15, 2004·Seminars in Nephrology·Michael S GoligorskyEisei Noiri
Sep 24, 1999·The Journal of Urology·M Saito, I Miyagawa
May 25, 2005·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Kishor Devalaraja-NarashimhaBabu J Padanilam
Sep 5, 1998·European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery·S C Weight, M L Nicholson
Nov 26, 2003·Current Opinion in Critical Care·An S De Vriese, Marc Bourgeois
Sep 16, 2004·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Ana Rodriguez-PeñaJose M Lopez-Novoa

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