PMID: 7519340Mar 14, 1994Paper

Increased nitric oxide synthase immunoreactivity in rat dorsal root ganglia in a neuropathic pain model

Neuroscience Letters
J H SteelJ M Polak

Abstract

In rats, tight ligation of L5 and L6 spinal nerves produces symptoms of thermal hyperalgesia and mechanical allodynia, mimicking the symptoms which characterise painful peripheral neuropathies in humans. Immunoreactivity for nitric oxide synthase (NOS) was investigated in lumbar (L1, L4, L5 and L6) dorsal root ganglia from naive controls and from rats surviving for 3, 7, and 14 days after unilateral ligation of the L5 and L6 spinal nerves. Quantitative analysis revealed significant increases in the percentage of NOS-immunoreactive cell profiles in L5 and L6 ganglia on the operated side at all time points, with the number of labelled profiles increasing with time following ligation, but L1 and L4 ganglia were unaffected. These findings suggest that nitric oxide may have a role in the generation and/or maintenance of neuropathic pain.

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Citations

Oct 1, 1995·The Histochemical Journal·D BlottnerR Gossrau
Jun 1, 1996·Journal of the Neurological Sciences·Y ChoiJ R Tobin
Dec 5, 1994·Neuroscience Letters·S V KoulchitskyV A Kulchitsky
Nov 27, 1998·European Journal of Pharmacology·M PozzaL Calzà
Feb 13, 2001·Journal of Neuroscience Methods·Y TakenobuK Kondo
Nov 5, 1997·Journal of Pain and Symptom Management·M Anbar, B M Gratt
Mar 6, 2002·British Journal of Pharmacology·Juan V Esplugues
Feb 5, 1999·Acta Anaesthesiologica Scandinavica. Supplementum·T Gordh
Oct 12, 2013·Molecular Neurobiology·Hamid Kalalian MoghaddamFatemeh Mahboobi
May 3, 2005·European Journal of Pain : EJP·Stanislava Jergova, Dasa Cizkova
Jan 20, 2006·The European Journal of Neuroscience·Peter J ShortlandSharon Averill
Apr 8, 2014·The European Journal of Neuroscience·Ben CoomberMark N Wallace
Dec 21, 2005·European Journal of Pharmacology·Ajit K NaikShailesh P Dudhgaonkar
Sep 27, 2005·Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics·Barton M Gratt, Michael Anbar
Oct 21, 2004·Brain Research·Shelley L DaviesFiona M Boissonade
Mar 26, 2015·Frontiers in Neurology·Ben CoomberMark Nelson Wallace
Apr 17, 2014·Antioxidants & Redox Signaling·Nikita Gamper, Lezanne Ooi
Dec 5, 2014·Canadian Journal of Physiology and Pharmacology·Narendra Kumar, Anand Kar
Jun 28, 2008·Pharmacology, Biochemistry, and Behavior·Francisca Pérez-SeverianoVinicio Granados-Soto
Jun 22, 2000·Anesthesiology·K OmoteA Namiki
May 29, 2001·Microscopy Research and Technique·S CalatayudJ V Esplugues
Jan 13, 2000·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·M KawakamiT Tamaki
Mar 5, 2003·Clinical Orthopaedics and Related Research·Tsukasa OnozawaXin Feng

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