Increased noradrenaline efflux induced by local infusion of fluoxetine in the rat frontal cortex

European Journal of Pharmacology
Z A Hughes, S C Stanford

Abstract

In microdialysis experiments in vivo, local infusion of either the selective serotonin reuptake inhibitor, fluoxetine, or the selective noradrenaline uptake inhibitor, desipramine, increased noradrenaline efflux in rat frontal cortex. Synaptosomal uptake of [3H]noradrenaline was used to test whether inhibition of uptake could contribute to this effect of fluoxetine. Low concentrations of fluoxetine were less effective than desipramine at inhibiting [3H]noradrenaline uptake; both compounds were more potent than the selective serotonin reuptake inhibitor, citalopram. To investigate whether this inhibition of uptake involved an action on noradrenergic neurones, experiments compared the effects of a noradrenergic lesion, induced by the neurotoxin N-(2-chloroethyl)-N-ethyl-2-bromobenzylamine (DSP-4), on the inhibition of uptake by fluoxetine, desipramine and citalopram. The lesion reduced [3H]noradrenaline uptake in the presence of fluoxetine and citalopram but increased it in the presence of desipramine. The results suggest both that inhibition of noradrenaline uptake could contribute to the actions of fluoxetine and that a non-noradrenergic mechanisms is a target for this action.

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Citations

Jun 18, 2005·Pharmacology, Biochemistry, and Behavior·Michel BourinMartine Hascoët
Apr 27, 2000·European Journal of Pharmacology·K HatanakaT Yamaguchi
Nov 5, 1999·Pharmacology, Biochemistry, and Behavior·A BessonJ Fialip
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May 19, 2004·Proceedings of the National Academy of Sciences of the United States of America·John F CryanIrwin Lucki
Aug 19, 2007·Journal of Asian Natural Products Research·Song LiMin-Wei Wang
Mar 3, 2005·Neuropsychobiology·Patrizia BlardiPaolo Castrogiovanni
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Oct 28, 2008·Stress : the International Journal on the Biology of Stress·Christopher A LowryCliff H Summers
Apr 4, 2006·Neuroscience and Behavioral Physiology·G T ShishkinaL V Anikina

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