PMID: 6112747Mar 1, 1981Paper

Increased nuclear conjugated polyamines and transglutaminase during liver regeneration

Proceedings of the National Academy of Sciences of the United States of America
M K Haddox, D H Russell

Abstract

The nuclear content of conjugated polyamines increased during rat liver regeneration. Conjugated polyamines isolated from the acid-precipitable fraction of nuclei required peptide bond hydrolysis for release of the parent compounds. The most striking change occurred in conjugated putrescine which fluctuated in a biphasic manner; maximal nuclear levels 12-fold and 25-fold above those of sham-operated controls were achieved at 4 and 42 hr after hepatectomy, respectively. Conjugated spermidine and spermine increased 3- and 2-fold respectively within 4 hr and remained high throughout the 48 hr studied. When expressed on the basis of mg of nuclear protein, the maximal conjugated putrescine increased 19-fold, conjugated spermidine increased 2-fold, and conjugated spermine decreased by 50%. Therefore, the spermidine and spermine conjugates may be of a more constitutive nature whereas the large changes in the nuclear conjugation of putrescine associated with the onset of growth may play a regulatory role. The nucleus also contained transglutaminase (R-glutaminyl-peptide:amine gamma-glutamyl-yltransferase, EC 2.3.2.13), an enzyme shown in vitro to conjugate polyamines covalently to proteins. The specific activity of the nuclear enzyme i...Continue Reading

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Citations

Nov 1, 1982·Biochemical Pharmacology·D H Russell, C A Manen
Jan 1, 1984·The International Journal of Biochemistry·M A Grillo, D C Pezzali
Jan 1, 1985·The International Journal of Biochemistry·M A Grillo
Aug 8, 1983·Life Sciences·A VanellaR Bernardini
Jan 1, 1991·Life Sciences·J H Gillette, J L Mitchell
Jan 1, 1983·Advances in Enzyme Regulation·D H Russell
May 1, 1984·Molecular and Cellular Endocrinology·D H RussellJ G Copeland
Jul 26, 1985·Biochimica Et Biophysica Acta·S BeninatiF Autuori
Jan 20, 1987·Biochimica Et Biophysica Acta·J HarsfalviL Fesus
Jul 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·K F ScottD H Russell
Mar 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·D H Russell
Jan 1, 1984·The Journal of Experimental Medicine·M P MurtaughP J Davies
Jul 1, 1988·Plant Physiology·D Serafini-FracassiniD D'Orazi
Feb 6, 2004·Biological & Pharmaceutical Bulletin·Naoko SatoYasuhito Ohkubo
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Oct 1, 1986·Biochimica Et Biophysica Acta·J F RichardsP W Gout
Nov 5, 2011·The FEBS Journal·Ting-Fang KuoSoichi Kojima
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Feb 26, 1982·Biochemical and Biophysical Research Communications·M MachA Ogilvie
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May 2, 1983·FEBS Letters·L FésüsJ Hársfalvi
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Apr 1, 1982·Journal of Cellular Physiology·K F Scott, D H Russell
Dec 1, 1981·Journal of Cellular Physiology·M K Haddox, D H Russell
Nov 1, 1982·Journal of Cellular Physiology·J A Remington, D H Russell
Sep 1, 1985·Journal of Cellular Physiology·G Korner, U Bachrach
Jan 1, 1984·Cell Biochemistry and Function·U Bachrach
Jan 1, 1984·Cell Biochemistry and Function·R Chayen
Apr 3, 2014·Physiological Reviews·Richard L EckertKapil Mehta

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