Increased number and activation of peripheral basophils in adult-onset minimal change disease.

Journal of Cellular and Molecular Medicine
Huanqin HanQingjun Pan

Abstract

Nowadays, the pathogenesis of minimal change disease (MCD) is still not well-known, and the current understanding on MCD is mainly based on data derived from children, and very few adults. Here, we comprehensively analysed the correlation between the changes of peripheral basophils and the incidence rate and relapse of adult-onset MCD. The results showed that in patients at the onset of MCD, the ratio and activation of basophils were all higher than those of healthy controls (all P < .05). In vitro test results showed that basophils from healthy controls can be activated by the serum taken from patients with MCD. Among 62 patients at the onset of MCD, with complete remission after treatment and 1 year of follow-up, the relative and absolute basophil counts before treatment were higher in the long-term remission group (n = 33) than that of the relapse group (n = 29). The basophil counts were significantly higher in the infrequent relapse group (n = 13) than that of the frequent relapse group (n = 16; P < .05). These findings suggested that basophil may play a pathogenic role in adult-onset MCD, and the increased number and activation of peripheral basophils could predict recurrence in adult MCD.

References

Jun 1, 1986·Kidney International·F NolascoD G Williams
Feb 13, 1982·Lancet·E PirotzkyC Noirot
May 1, 1997·Clinical and Experimental Immunology·Y YanagiharaH Saito
Nov 10, 2001·Experimental Nephrology·J Khoshnoodi, K Tryggvason
Mar 6, 2002·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Masaru NakayamaSatoru Fujimi
Dec 23, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Asta ValanciutéDjillali Sahali
Mar 20, 2004·International Archives of Allergy and Immunology·Hans-Jörg BühringPeter Valent
May 24, 2008·BMJ : British Medical Journal·Richard P Hull, David J A Goldsmith
Aug 21, 2009·Kidney International·Matthias Mack, Alexander R Rosenkranz
Feb 4, 2010·Immunology and Cell Biology·Mark C SiracusaDavid Artis
Mar 3, 2010·Annual Review of Immunology·Jinfang ZhuWilliam E Paul
Jun 10, 2010·Cytometry. Part B, Clinical Cytometry·Eva M SturmGunter J Sturm
Mar 27, 2012·Clinical Nephrology·Kohei MiyazakiTsukasa Takemura
Apr 6, 2013·Nature Reviews. Immunology·David Voehringer
Apr 25, 2013·Nature Communications·Atsushi OtsukaKenji Kabashima
Apr 16, 2014·Cytometry. Part a : the Journal of the International Society for Analytical Cytology·Dorothea DijkstraJens M Hohlfeld
Sep 5, 2014·Experimental and Therapeutic Medicine·Qingjun PanHuafeng Liu
Jul 7, 2015·Clinical and Experimental Immunology·R BertelliG M Ghiggeri
Apr 20, 2016·F1000Research·Moin A Saleem, Yasuko Kobayashi
Dec 13, 2016·Clinical Journal of the American Society of Nephrology : CJASN·Marina VivarelliFrancesco Emma
Jan 17, 2017·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Rutger J MaasJack F Wetzels
Jun 29, 2017·Immunological Reviews·Yoshinori YamanishiHajime Karasuyama
Sep 28, 2017·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·Qingjun PanHua-Feng Liu
Feb 13, 2018·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·P KorošecP J Turner
Feb 22, 2018·Nature Communications·Christophe PellefiguesNicolas Charles
Jul 2, 2018·Current Opinion in Immunology·Masato Kubo
Sep 1, 2018·International Immunology·Hajime KarasuyamaYoshinori Yamanishi
Dec 26, 2018·International Journal of Molecular Sciences·Yuhki YanaseMichihiro Hide
Apr 7, 2019·Clinical Journal of the American Society of Nephrology : CJASN·Stephen M Korbet, William L Whittier

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Methods Mentioned

BETA
flow cytometry

Software Mentioned

SPSS
FlowJo

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