Increased number of anaerobic bacteria in the infected root canal in type 2 diabetic rats

Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics
Akihiro IwamaHiroshi Nakamura

Abstract

The purpose of this study was to investigate the relationship between type 2 diabetes mellitus and anaerobic bacteria detected in infected root canals. Normal Wistar rats (control) received a standard laboratory diet with water (group A), and GK rats (type 2 diabetes mellitus rats) a normal laboratory diet with water (group B) or a 30% sucrose solution (group C). Chemotaxis assay was conducted on polymorphonuclear leukocytes from the 3 groups, and the numbers of anaerobic bacteria in infected root canals were determined. In the chemotaxis assay on the polymorphonuclear leukocytes, the chemotactic response of cells in group C was lower than that for groups A and B (P < .01). As to bacteria detected in the root canal, obligate anaerobic bacteria which stained gram negative, were significantly more numerous in group C (P < .01) than in groups A and B. The metabolic condition produced by type 2 diabetes mellitus in rats might lower the general host resistance against bacterial infection.

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Citations

Apr 25, 2013·Journal of Endodontics·Carlos Frederico B WolleMaria M Campos
Nov 17, 2009·Archives of Oral Biology·Masahito TsujiHiroshi Nakamura
Sep 17, 2008·Journal of Endodontics·Mariana Ferreira LeiteJosé Nicolau
May 16, 2008·International Endodontic Journal·M YamasakiH Nakamura
Feb 28, 2013·International Endodontic Journal·S M F LimaT M B Rezende
Sep 30, 2014·Dental Traumatology : Official Publication of International Association for Dental Traumatology·João Eduardo Gomes-FilhoLuciano Tavares Angelo Cintra
Sep 11, 2016·International Endodontic Journal·L T A CintraA L F Briso
Jul 30, 2019·International Endodontic Journal·L Cosme-SilvaJ E Gomes-Filho
Nov 26, 2015·Clinical Oral Investigations·Renato Felipe PereiraDoris Hissako Sumida

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