PMID: 6983116Oct 1, 1982Paper

Increased number of IgG Fc receptors on monocyte-enriched peripheral blood leucocytes from patients with rheumatoid arthritis

Scandinavian Journal of Immunology
J Møller RasmussenS E Svehag

Abstract

The number of free Fc receptors (FcR) per cell and the association constant (Kass) for the binding of monomeric IgG were determined for monocyte-enriched peripheral blood mononuclear cells, isolated from 16 patients with active classical rheumatoid arthritis (RA) and from 15 normal healthy donors. The assay system was based on binding under equilibrium conditions of 125I-labelled monomeric rabbit IgG to monocytes purified from peripheral blood on a continuous gradient of Percoll. Monocytes from 14 untreated RA patients (6 seropositive, 8 seronegative) expressed on the average 4.8 +/- 1.3 x 10(4) FcR/cell. This number was significantly higher (P less than 0.001) than that found in the control group (34. +/- 0.7 x 10(4) FcR/cell). There was also a significant difference between the mean Kass of the RA group and the control group--2.1 +/- 0.7 x 10(8) l/mol and 2.6 +/- 1.0 x 10(8) l/mol, respectively (0.05 greater than P greater than 0.01). Two seropositive RA patients receiving systemic treatment with penicillamine expressed the same number of FcR/cell as the mean of the control group (3.6 x 10(4)). Levels of circulating immune complexes (CIC) and the complement-factor C3 split product C3d were also measured. No correlation was fo...Continue Reading

References

Jun 13, 1975·Annals of the New York Academy of Sciences·R Evans
Jan 1, 1978·Agents and Actions·A C AllisonH U Schorlemmer
Feb 1, 1979·Annals of the Rheumatic Diseases·M KávaiG Szegedi
Jul 1, 1979·Proceedings of the Society for Experimental Biology and Medicine·N E Kay, S D Douglas
May 1, 1968·The Biochemical Journal·J W Prahl, R R Porter

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Citations

Jan 1, 1984·Folia Microbiologica·L Fornůsek, V Vĕtvicka
Oct 31, 1983·Clinica Chimica Acta; International Journal of Clinical Chemistry·I BrandslundS E Svehag
Jun 1, 1984·Annals of the Rheumatic Diseases·S D CarterP A Dieppe
Jan 1, 1984·Scandinavian Journal of Rheumatology·G G RasmussenA Jensen
Jul 6, 1984·Science·N KhansariH H Fudenberg

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