PMID: 9450814Feb 5, 1998Paper

Increased number of peripheral blood CD34+ cells in lithium-treated patients

British Journal of Haematology
A BallinD Meytes

Abstract

Eight adult patients with bipolar disorder were prospectively examined to find whether lithium carbonate increased their peripheral blood CD34+ haemopoietic stem cells. Following lithium therapy for 3-4 weeks their neutrophil counts increased by a mean of 88% (from 4625 +/- 1350 x 10(9)/l, mean +/- SD pretreatment, to a peak of 8300 +/- 3910 x 10(9)/l). Concommitantly, there was a significant increment in their CD34+ cells (from 0.11 +/- 0.01% to a peak of 0.18 +/- 0.08%). There was a significant correlation between the rise in neutrophil count and that of the CD34+ cells (r = 0.795, P = 0.019). Lithium therapy may be used to mobilize peripheral blood CD34+ cells for marrow transplantation.

References

Jan 31, 1980·The New England Journal of Medicine·G H LymanD Preston
Mar 1, 1982·Cell and Tissue Kinetics·V S Gallicchio, M G Chen
Aug 21, 1996·Journal of the National Cancer Institute·S Jenks

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Citations

Nov 30, 2011·Current Opinion in Hematology·Mario Petrini, Antonio Azzarà
Jun 18, 1999·Annals of the New York Academy of Sciences·T Papayannopoulou
Mar 27, 2001·Annual Review of Pharmacology and Toxicology·C J Phiel, P S Klein
Dec 5, 2009·The Journal of Clinical Investigation·Jian HuangPeter S Klein
Feb 29, 2016·Pharmacological Reports : PR·Ewa Ferensztajn-Rochowiak, Janusz K Rybakowski
Oct 28, 2008·Experimental Hematology·Sachin Malhotra, Paul W Kincade
Dec 1, 2003·Acta Neuropsychiatrica·B Corbella, E Vieta
Dec 2, 2005·Toxicology Letters·Waldemar WagnerJarosław Dastych
Dec 6, 2000·Immunopharmacology and Immunotoxicology·E CapodicasaR Biondi
Nov 7, 2008·International Journal of Dermatology·Mohammad Jafferany
Dec 13, 2017·Journal of Clinical Psychopharmacology·John J Mooney, Roscoe O Brady
Aug 30, 2008·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Mohsen Nokhbatolfoghahai, Kazem Parivar
Jun 17, 2014·Oncotarget·James A McCubreyMelchiorre Cervello
Apr 4, 2021·Leukemia·Alberto M MartelliJames A McCubrey

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