Increased number of substance P positive nerve fibres in interstitial cystitis

British Journal of Urology
X PangT C Theoharides

Abstract

To explore the presence of the neuropeptide substance P (SP) in the bladders of rats and humans and to investigate its relationship to mast cells (MCs) in interstitial cystitis (IC), a bladder disorder which occurs mostly in women and is characterized by frequency of voiding, nocturia and debilitating suprapubic pain. Bladder biopsies from eight women with untreated IC (mean age 36 years, range 29-58) and five control patients with no IC were analysed and compared with each other and with bladder tissue from 12 rats. Immunohistochemistry and image analysis were used to examine the density of SP-positive nerve fibres and their relationship with MCs. SP-containing nerve fibres were present in the bladder of both rats and humans. They were increased only in the submucosa, but not in the detrusor, of IC patients and were frequently seen in juxtaposition to MCs. SP, a neuropeptide secreted from sensory nerve endings, has been implicated in the pathophysiology of pain and has been shown to trigger MC secretion. Moreover, MC secretion by SP is augmented by oestradiol and bladder MCs have been shown to express high affinity oestrogen receptors. A functional relationship between SP and MCs may explain the pathophysiology of the neuro-in...Continue Reading

References

May 1, 1992·Cellular Immunology·A I RobertsE C Ebert
Jan 1, 1992·International Archives of Allergy and Immunology·H VliagoftisT C Theoharides
Oct 1, 1992·The Journal of Urology·S K YunP E Zimmern
Mar 1, 1992·The Journal of Urology·M HohenfellnerE A Tanagho
Nov 1, 1991·British Journal of Urology·T J Christmas, J Rode
Aug 1, 1991·British Journal of Urology·D E NurseA R Mundy
Sep 1, 1991·The American Journal of Surgical Pathology·S L Johansson, M Fall
Jan 1, 1990·Virchows Archiv. A, Pathological Anatomy and Histopathology·T J ChristmasR T Turner-Warwick
Jul 31, 1990·Neuroscience Letters·L NordlingT Lundeberg
Nov 27, 1990·Neuroscience Letters·M G Blennerhassett, J Bienenstock
Feb 1, 1990·The Journal of Urology·P HannoA J Wein
Jan 1, 1987·Annals of the New York Academy of Sciences·A M StaniszJ Bienenstock
Sep 1, 1988·British Journal of Pharmacology·M A LowmanM K Church
Apr 1, 1989·Agents and Actions·M K ChurchR C Benyon
Oct 1, 1987·The Journal of Urology·W L LynesT A Stamey
Sep 1, 1987·The Journal of Urology·M Holm-BentzenR Barnard
Jan 1, 1987·The Journal of Urology·M FallF Aldenborg
Sep 1, 1982·The Journal of Physiology·C M FewtrellJ M Stewart
Jun 1, 1982·British Journal of Urology·S LarsenJ A Gosling
Feb 1, 1994·Proceedings of the National Academy of Sciences of the United States of America·C PothoulakisS E Leeman
Aug 1, 1994·The Journal of Urology·M el-MansouryT C Theoharides
Mar 1, 1993·The Journal of Urology·J A KoziolE M Tan
Apr 1, 1993·British Journal of Urology·T LundebergP Ekman
Feb 1, 1949·The Journal of Urology·J R HAND

❮ Previous
Next ❯

Citations

Sep 24, 1998·International Urogynecology Journal and Pelvic Floor Dysfunction·D R Erickson, M F Davies
Mar 14, 2008·International Urogynecology Journal and Pelvic Floor Dysfunction·M CervigniD Porru
Feb 23, 2013·International Urogynecology Journal·I OffiahB A O'Reilly
Mar 7, 2008·Journal of Neural Transmission·A Apostolidis, C J Fowler
Aug 1, 2002·Current Urology Reports·Robert M Moldwin
Oct 30, 2009·Current Urology Reports·Brian E Mayson, Joel M H Teichman
Jun 18, 2005·Brain Research. Brain Research Reviews·Theoharis C TheoharidesAphrodite Konstantinidou
May 5, 2005·Experimental Neurology·Adrian SculptoreanuLori A Birder
Dec 31, 2003·Journal of Neuroimmunology·Theoharis C Theoharides, David E Cochrane
May 17, 2000·European Journal of Pharmacology·T DoiH Natsugari
May 30, 2001·Urology·D E Bjorling, Z Y Wang
Jun 15, 1999·Urology·P C SteinC L Parsons
Dec 13, 2002·The Urologic Clinics of North America·James Chivian LukbanGrannum R Sant
Sep 24, 1999·Journal of Women's Health & Gender-based Medicine·D R Erickson
Dec 9, 2000·Current Opinion in Obstetrics & Gynecology·A RosamiliaP L Dwyera
Feb 28, 2002·Clinical Obstetrics and Gynecology·Robert M Moldwin, Grannum R Sant
Jun 24, 1999·The Journal of Urology·D E BjorlingR Saban
May 20, 1998·Obstetrical & Gynecological Survey·A Rosamilia, P L Dwyer
Aug 26, 1998·International Journal of Urology : Official Journal of the Japanese Urological Association·T YamadaH Taguchi
Jul 1, 1995·British Journal of Urology·W BoucherT C Theoharides
Jun 18, 1998·Annals of the New York Academy of Sciences·T C TheoharidesG R Sant
Dec 25, 2009·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Birthe SchnegelsbergDebra A Cockayne
Oct 27, 2011·Advances in Urology·Jochen NeuhausJens-Uwe Stolzenburg
Jul 27, 2011·Therapeutic Advances in Urology·Sonal GroverAlexis E Te
Nov 17, 2009·BMC Urology·Charles N RudickDavid J Klumpp
Apr 5, 2008·Endocrinology·Anuradha ChakrabartyPeter G Smith
Apr 24, 2010·JSLS : Journal of the Society of Laparoendoscopic Surgeons·Maurice K ChungCherie W Chung
Jun 7, 2014·Current Urology Reports·Tarek HassounaArmando J Lorenzo
Mar 11, 2004·Journal of Pediatric and Adolescent Gynecology·T F Mattox
May 25, 2010·Journal of Women's Health·Charles W ButrickPeter K Sand

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.