Increased numbers of circulating haematopoietic progenitor cells after treatment with high-dose interleukin-2 in cancer patients

British Journal of Haematology
M R SchaafsmaJ H Falkenburg

Abstract

Immunotherapy with recombinant interleukin-2 (IL-2) and lymphokine-activated killer (LAK) cells has been applied to patients with metastatic cancers for its antitumour activity. In the present study we investigated the effects of in vivo administration of IL-2 (3 x 10(6) U/m2/d, continuously i.v.) on haematopoiesis. Six patients with disseminated renal cell carcinoma, treated with IL-2 and LAK cells, were monitored for the numbers of white blood cells and circulating haematopoietic progenitor cells (HPC). During IL-2 treatment lymphopenia developed, followed by lymphocytosis after discontinuation of IL-2 infusions. IL-2 administration also resulted in neutrophilia and eosinophilia. Absolute numbers of circulating HPC declined markedly during IL-2 treatment. However, after completing IL-2 infusions, the numbers of circulating erythroid (BFU-E), myeloid (CFU-GM) and multipotential progenitor cells (CFU-GEMM) strongly increased, reaching a maximum after 5 d (day 10 from the start of IL-2 treatment). This increase did not result from repeated leucaphereses, since patients treated with IL-2 alone showed a similar response. In comparison with pretreatment levels the pool of circulating HPC expanded about 20-fold. This study illustrat...Continue Reading

References

Jul 1, 1987·British Journal of Haematology·L B To, C A Juttner
Apr 1, 1988·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·J A ThompsonA Fefer

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Citations

Apr 1, 2003·The Veterinary Record·F D MenziesE A Goodall
Nov 30, 2006·The International Journal of Psycho-analysis·Walker Shields
Jan 1, 1995·Cancer Chemotherapy and Pharmacology·P M PolitiJ M Hamilton
May 22, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·B PeláezJ L Subiza

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