PMID: 9645266Jun 30, 1998Paper

Increased numbers of circulating interferon-gamma- and interleukin-4-secreting cells during normal pregnancy

American Journal of Reproductive Immunology : AJRI
L MatthiesenJan Ernerudh

Abstract

Systemic immune responses during normal pregnancy are suggested to deviate toward secretion of T helper (Th)2-like cytokines. Blood samples from 11 healthy primigravidae in their first, second, and third trimesters, and 8 weeks postpartum were examined. Peripheral blood mononuclear cells were separated and the numbers of interferon (IFN)-gamma- and interleukin (IL)-4-secreting cells were identified by using the enzyme-linked immunospot test. In all three trimesters of pregnancy, and also postpartum, the numbers of IFN-gamma- and IL-4-secreting cells were significantly higher compared with nonpregnant controls (Mann-Whitney; P < 0.001). The numbers of IFN-gamma- and IL-4-secreting cells gradually increased as the pregnancy progressed compared with postpartum (Kruskas-Wallis; P < 0.01 and P < 0.05, for IFN-gamma and IL-4, respectively). The ratios of IFN-gamma/IL-4 during pregnancy and postpartum were unchanged, and also when compared with nonpregnant controls. The results indicate a systemic up-regulation of both Th1- and Th2-like immune responses during normal pregnancy.

References

Jan 1, 1992·Advances in Parasitology·L Brabin, B J Brabin
Jun 1, 1992·Clinical Rheumatology·J A Da Silva, T D Spector
Sep 1, 1991·Journal of Reproductive Immunology·D W Dresser
Nov 1, 1984·Reviews of Infectious Diseases·E D Weinberg
Aug 1, 1980·Drugs·M J Miller
Nov 1, 1994·The Journal of Experimental Medicine·M K RackeM Röcken
Aug 1, 1995·Immunology Today·A Kelso
Dec 1, 1994·The Journal of Allergy and Clinical Immunology·R A Seder
Jan 1, 1995·Annals of the Rheumatic Diseases·J A Da Silva
Oct 1, 1993·Research in Immunology·S L Swain
Jan 1, 1994·Annual Review of Immunology·R A Seder, W E Paul
Mar 1, 1996·Immunology Today·T R Mosmann, S Sad
Aug 1, 1996·Journal of Reproductive Immunology·J Szekeres-Bartho, T G Wegmann

❮ Previous
Next ❯

Citations

Feb 26, 2013·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Annette Langer-Gould, Brandon E Beaber
May 17, 2005·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Jacek R Wilczyński
Aug 5, 2003·Journal of Reproductive Immunology·Shigeru Saito, Masatoshi Sakai
Aug 16, 2002·Transplant Immunology·Monika Ostensen, Peter M Villiger
Jan 13, 2000·Clinical and Experimental Immunology·N KruseP Rieckmann
Dec 2, 1999·American Journal of Reproductive Immunology : AJRI·S SaitoN Narita
Jun 22, 2012·Mediators of Inflammation·Lynne SykesPhillip R Bennett
Nov 30, 2006·The Journal of Reproduction and Development·Chang-Long NanDa-Yuan Chen
Jul 12, 2007·Seminars in Immunopathology·Monika Ostensen, Peter M Villiger
Feb 11, 2011·Autoimmunity·Sabina Resic LindehammerUNKNOWN Diabetes and Celiac Disease Prediction in Scania Study Group
Apr 24, 2007·Journal of Reproductive Immunology·Nicolas M OrsiJames J Walker
Jun 23, 2009·Journal of Reproductive Immunology·Martina SandbergMaria C Jenmalm
Jul 13, 2012·Journal of Reproductive Immunology·Marie PerssonMaria C Jenmalm
Mar 22, 2008·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Jennifer A BrewsterJames J Walker
Sep 6, 2000·Clinical Endocrinology·J H Lazarus, A Kokandi
Jul 20, 1999·Biology of Reproduction·A A Ashkar, B A Croy
Mar 14, 2008·American Journal of Reproductive Immunology : AJRI·Victor P ChernyshovVladimir I Bannikov
Jan 17, 2004·American Journal of Reproductive Immunology : AJRI·Chikako KatoHideo Honjo
Jun 24, 2004·American Journal of Reproductive Immunology : AJRI·Yvonne JonssonLeif Matthiesen
Mar 3, 2009·Nihon Rinshō Men'eki Gakkai kaishi = Japanese journal of clinical immunology·Shuzo YoshidaToshiaki Hanafusa
Jun 6, 2009·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·Liza Anne BrecklerSusan L Prescott
Dec 26, 2001·Endocrinology·M ImaizumiT F Davies
Jul 21, 2006·Annals of the New York Academy of Sciences·Monika ØstensenPeter M Villiger
Jun 19, 2002·American Journal of Reproductive Immunology : AJRI·C EkerfeltJ Ernerudh
Jul 8, 2011·American Journal of Reproductive Immunology : AJRI·Jan ErnerudhJenny Mjösberg
Jun 12, 2003·American Journal of Reproductive Immunology : AJRI·H KojimaH Honjo
Aug 20, 2019·American Journal of Reproductive Immunology : AJRI·Stacia Z McIntoshRyan L Ashley
Oct 5, 2016·Archives of Women's Mental Health·Linnea KarlssonHasse Karlsson
Jun 22, 1999·American Journal of Reproductive Immunology : AJRI·M PalfiJ Ernerudh

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.