Increased numbers of lymphocytes with single class surface immunoglobulins in reactive hyperplasia of lymphoid tissue

American Journal of Clinical Pathology
M PalutkeG Carrillo

Abstract

Forty-seven lymph nodes and one stomach exhibiting reactive hyperplasia from 40 patients were examined by morphologic and immunologic methods. Twelve lymph nodes and one stomach from ten patients had a significantly increased number (greater than 25%) of lymphocytes, with single class surface immunoglobulins or plasma cells, and plasmacytoid lymphocytes secreting single class immunoglobulins. In three cases, a diagnosis of malignancy was subsequently made on the basis of morphological and immunological evidence of tumor in other tissue. Five patients had collagen disorders, two had a persistent unexplained hypergammaglobulinemia, and two had no recognized associated disease. The significance of an increase of B lymphocytes with single class surface immunoglobulins in these cases is presently not clear, but patients with similar findings should have extensive investigation and persistent follow-up.

Citations

Jul 11, 1998·Journal of Clinical Pathology·M D JeffersM McKean
May 1, 1993·Journal of Veterinary Internal Medicine·D F EdwardsR G Helman
Feb 1, 1990·Clinical and Experimental Immunology·S MatsubayashiR Volpé
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