Increased osteoblast adhesion on physically optimized KRSR modified calcium aluminate

Journal of Biomedical Materials Research. Part a
Rachelle N PalcheskoEllen S Gawalt

Abstract

Calcium aluminate (CA) is a porous biocompatible material easily cast at room temperature. Through this casting process, the average surface pore size of CA was varied from an average of 100 to 290 microns. The optimal surface pore size of the hydrated CA for cell viability was determined to be 100 microns. Further, a three step-solution deposition technique was developed to covalently immobilize cell adhesion peptides, RGD, and KRSR to the CA surface. Cell adhesion for 1-, 4-, and 7-day time periods was tested with primary osteoblasts and NIH 3T3 fibroblasts. Both peptides were found to increase fibroblast adhesion to the CA surface. However, only KRSR increased osteoblast adhesion to the surface of the CA, which may aid in bone formation after implantation.

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Citations

Feb 2, 2013·Journal of Materials Science. Materials in Medicine·ShengJun SunFuQiang Zhang
May 10, 2016·Materials Science & Engineering. C, Materials for Biological Applications·Gavin A BuckholtzEllen S Gawalt
Oct 28, 2016·Journal of Biomedical Materials Research. Part a·Małgorzata K Włodarczyk-BiegunMarleen Kamperman
Oct 31, 2016·Journal of Controlled Release : Official Journal of the Controlled Release Society·Rick VisserJose Becerra
May 26, 2016·PloS One·Małgorzata K Włodarczyk-BiegunMarleen Kamperman
Jul 13, 2016·BMC Medicine·Ippokratis PountosPeter V Giannoudis

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