Increased Oxidative and Nitrative Stress Accelerates Aging of the Retinal Vasculature in the Diabetic Retina

PloS One
Folami LamokeManuela Bartoli

Abstract

Hyperglycemia-induced retinal oxidative and nitrative stress can accelerate vascular cell aging, which may lead to vascular dysfunction as seen in diabetes. There is no information on whether this may contribute to the progression of diabetic retinopathy (DR). In this study, we have assessed the occurrence of senescence-associated markers in retinas of streptozotocin-induced diabetic rats at 8 and 12 weeks of hyperglycemia as compared to normoglycemic aging (12 and 14 months) and adult (4.5 months) rat retinas. We have found that in the diabetic retinas there was an up-regulation of senescence-associated markers SA-β-Gal, p16INK4a and miR34a, which correlated with decreased expression of SIRT1, a target of miR34a. Expression of senescence-associated factors primarily found in retinal microvasculature of diabetic rats exceeded levels measured in adult and aging rat retinas. In aging rats, retinal expression of senescence associated-factors was mainly localized at the level of the retinal pigmented epithelium and only minimally in the retinal microvasculature. The expression of oxidative/nitrative stress markers such as 4-hydroxynonenal and nitrotyrosine was more pronounced in the retinal vasculature of diabetic rats as compared ...Continue Reading

References

Sep 26, 1995·Proceedings of the National Academy of Sciences of the United States of America·G P DimriO Pereira-Smith
Apr 1, 1995·The British Journal of Ophthalmology·A W StittD B Archer
May 9, 1995·Proceedings of the National Academy of Sciences of the United States of America·Q ChenB N Ames
May 10, 1994·Proceedings of the National Academy of Sciences of the United States of America·Q Chen, B N Ames
Aug 26, 1998·The Journal of Clinical Investigation·A J BarberT W Gardner
Aug 30, 2001·Experimental Gerontology·T C Squier
Jun 29, 2002·Circulation Research·Jun ChenMichael S Goligorsky
Feb 13, 2003·American Journal of Physiology. Endocrinology and Metabolism·Shali ChenSubrata Chakrabarti
Mar 14, 2003·Proceedings of the National Academy of Sciences of the United States of America·Wesley FarrisSuzanne Guenette
Dec 4, 2003·Diabetes/metabolism Research and Reviews·Ruth B CaldwellR William Caldwell
Mar 4, 2005·The International Journal of Biochemistry & Cell Biology·Ittai Ben-Porath, Robert A Weinberg
Mar 27, 2007·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·A B El-RemessyR B Caldwell
Oct 4, 2007·American Journal of Physiology. Endocrinology and Metabolism·Irina G ObrosovaMark A Yorek
Apr 2, 2008·Investigative Ophthalmology & Visual Science·Mohamed Al-ShabraweyRuth B Caldwell
Feb 3, 2009·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Jena J SteinleLisa S McFayden-Ketchum
Feb 19, 2009·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Steven N Austad
Feb 28, 2009·Aging Cell·Leocadio Rodríguez-MañasCarlos F Sánchez-Ferrer
Mar 23, 2010·Proceedings of the National Academy of Sciences of the United States of America·D Michiel PegtelJaap M Middeldorp
Apr 20, 2010·Diabetes Research and Clinical Practice·Weili ZhongJin Zhang
Jan 11, 2011·The British Journal of Ophthalmology·Hae Young-Lopilly ParkChan Kee Park
Jan 29, 2011·Arteriosclerosis, Thrombosis, and Vascular Biology·Deepak VenkateshSumithra Urs
Mar 1, 2011·Experimental Eye Research·Folami LamokeManuela Bartoli
Nov 8, 2011·Investigative Ophthalmology & Visual Science·Shunsuke KubotaKazuo Tsubota
Nov 22, 2011·Mechanisms of Ageing and Development·Huafei ZouFerruccio Galbiati
Dec 22, 2011·Biochimica Et Biophysica Acta·V CalabreseP Castellino
May 1, 2012·Survey of Ophthalmology·Sobha SivaprasadJennifer Evans
May 29, 2012·Current Diabetes Reports·Shuang WangElia J Duh
Jul 12, 2012·Frontiers in Physiology·Mariam El AssarLeocadio Rodríguez-Mañas
Oct 25, 2012·PloS One·Francesco RussoAlfredo Ferro
Jan 12, 2013·Investigative Ophthalmology & Visual Science·Michael LastaLeopold Schmetterer
May 2, 2013·Investigative Ophthalmology & Visual Science·Qing ZhongRenu A Kowluru
Jun 8, 2013·Journal of Cellular Biochemistry·Luigi ServilloMaria Luisa Balestrieri
Aug 7, 2013·Journal of the American Heart Association·Angelo AvogaroGian Paolo Fadini
Nov 5, 2013·Trends in Endocrinology and Metabolism : TEM·Rafael SimóUNKNOWN European Consortium for the Early Treatment of Diabetic Retinopathy (EUROCONDOR)

❮ Previous
Next ❯

Citations

Mar 30, 2017·European Journal of Pharmacology·Aarti V Shah, Martin R Bennett
Feb 7, 2018·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Xiaobing QianQianying Gao
Dec 24, 2019·Aging·Menaka C Thounaojam, Manuela Bartoli
Jun 9, 2017·Oxidative Medicine and Cellular Longevity·Huaije BuPidder Jansen-Dürr
Feb 9, 2020·Journal of Clinical Medicine·Esraa ShoshaRuth B Caldwell
Jul 15, 2020·Antioxidants·Hossameldin AbouhishManuela Bartoli
Apr 10, 2019·Oxidative Medicine and Cellular Longevity·Nidhi MahajanRajat Sandhir
Mar 16, 2019·Frontiers in Aging Neuroscience·Emiliano TriasLuis Barbeito
Jan 15, 2020·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Xiangji PanJuan Ye
Mar 28, 2020·Oxidative Medicine and Cellular Longevity·Parameswaran G SreekumarRam Kannan
May 2, 2018·Clinical & Translational Immunology·Raelene J PickeringJudy B de Haan
Apr 21, 2018·International Journal of Molecular Sciences·Esraa ShoshaRuth B Caldwell
Feb 16, 2021·Frontiers in Cell and Developmental Biology·José Antonio de Mera-RodríguezJavier Francisco-Morcillo
Mar 17, 2018·Progress in Retinal and Eye Research·Ximena Corso-DíazAnand Swaroop
Jun 2, 2021·Annual Review of Vision Science·Laura CampelloAnand Swaroop
Oct 27, 2021·Cellular and Molecular Life Sciences : CMLS·Angela RaucciEstella Zuccolo

❮ Previous
Next ❯

Methods Mentioned

BETA
light microscopy
PCR

Software Mentioned

Axiovision

Related Concepts

Related Feeds

Cell Aging (Keystone)

This feed focuses on cellular aging with emphasis on the mitochondria, autophagy, and metabolic processes associated with aging and longevity. Here is the latest research on cell aging.

Aging & Diabetes

This feed focuses on the role of the aging process on developing diabetes.

Biomarkers for Diabetes

This feed focuses on the latest research on biomarkers used for monitoring disease progression in diabetes.