Increased oxidative DNA damage and impaired antioxidant defense system in patients with gastrointestinal cancer

European Journal of Internal Medicine
Aymelek GönençBolkan Simşek

Abstract

Highly active intermediates are formed in aerobic metabolism which in turn leads to cellular damage. It is increasingly proposed that free radicals play a key role in human cancer development. The aim of this study was to investigate changes in 8-hydroxy-deoxyguanosine, nitrite+nitrate, total glutathione, total antioxidant capacity levels and superoxide dismutase, catalase, glutathione peroxidase activities in operative patients with gastrointestinal cancer before and after surgery and compare with inoperative patients. Oxidative stress parameters were measured in 59 gastrointestinal cancer patients and 20 controls. 8-hydroxy-deoxyguanosine was quantitated by Elisa method. Superoxide dismutase, catalase, glutathione peroxidase were assayed with colorimetric methods; Nitrite+nitrate, total glutathione and total antioxidant capacity were assayed with spectrophotometric methods. 8-hydroxy-deoxyguanosine levels in cancer patients were higher than those of control group (p<0.01). Similarly, glutathione levels were increased compared with controls (p<0.01). However, nitrite+nitrate, total antioxidant capacity levels and superoxide dismutase and catalase activities were decreased in cancer patients compared with controls (p<0.01, p<0....Continue Reading

References

Jan 1, 1988·Annual Review of Pharmacology and Toxicology·I A CotgreaveS Orrenius
Sep 23, 1994·Cell·C Nathan, Q W Xie
Oct 1, 1995·Mutation Research·V A Bohr, R M Anson
Sep 1, 1997·Medical and Pediatric Oncology·D J MalvyO Amédée-Manesme
Jan 1, 1997·Free Radical Biology & Medicine·B E Van DrielC J Van Noorden
Jul 29, 1998·The Journal of Urology·O T JanssonN P Wiklund
May 13, 1999·Biochimica Et Biophysica Acta·R P PatelV M Darley-Usmar
Jun 25, 1999·Free Radical Biology & Medicine·R ReC Rice-Evans
Feb 26, 2000·Carcinogenesis·L J Marnett
Aug 19, 2000·Diseases of the Colon and Rectum·S C BarrancoP Kolm
Apr 11, 2001·Urology·T L DeWeeseL J Marnett
May 29, 2001·Current Medicinal Chemistry·P Kovacic, J D Jacintho
Oct 12, 2001·Journal of Toxicology and Environmental Health. Part a·E SkrzydlewskaI Kasacka
Jul 12, 2002·Japanese Journal of Clinical Oncology·Ebubekir BakanMetehan Gumus
Jun 18, 2003·Clinica Chimica Acta; International Journal of Clinical Chemistry·Anna PastoreFiorella Piemonte
Jul 2, 2003·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Marcus S CookeJoseph Lunec
Oct 22, 2003·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·H TapieroK D Tew
Jan 8, 2005·World Journal of Gastroenterology : WJG·Elzbieta SkrzydlewskaMariola Sulkowska
Sep 6, 2005·Cell Biochemistry and Function·Chih-Ching YehLi-Yu Tsai
Nov 2, 2005·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Surong MeiGuowang Xu
Feb 1, 2006·Cell Biochemistry and Function·Derya Erten SenerMeral Torun
Dec 8, 2006·The Biochemical Journal·Barry Halliwell
Mar 31, 2007·Physiological Measurement·Anikó SomogyiGéza Nagy
Jun 16, 2007·European Journal of Nutrition·Chun-che Lin, Mei-chin Yin
Oct 8, 2008·Biomedical and Environmental Sciences : BES·Dong ChangHong-Zhi Pan
Mar 11, 2009·Clinical Biochemistry·Marika CrohnsPirkko Kellokumpu-Lehtinen
May 26, 2009·Clinical Biochemistry·Zorica Arsova-SarafinovskaAhmet Aydin
Jun 16, 2009·European Journal of Internal Medicine·Yalcin KekecGulsah Seydaoglu

❮ Previous
Next ❯

Citations

Dec 12, 2012·Journal of Biochemical and Molecular Toxicology·Meihong XuCailing Hou
Jun 14, 2014·Clinical Endocrinology·Ioannis KaramouzisEmanuela Arvat
Dec 2, 2014·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Suzan TaburErsin Akarsu
Nov 18, 2015·Oxidative Medicine and Cellular Longevity·Antonio Luiz Gomes JúniorAna Amélia de Carvalho Melo Cavalcante
Mar 21, 2017·International Journal of Cancer. Journal International Du Cancer·Long ZhangMingyao Liu
Sep 25, 2019·International Journal of Molecular Sciences·Daniela Bender, Eberhard Hildt

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.