Increased oxidative stress and plasma Hsp70 levels among gasoline filling station attendants

Toxicology and Industrial Health
Bing XiaXiaobo Yang

Abstract

Methylcyclopentadienyl manganese tricarbonyl (MMT) is an organic derivative of manganese (Mn) and is used as an antiknock agent and octane enhancer in gasoline. In this article, we tested the oxidative stress and heat stress protein (Hsp) 70 levels of gasoline station attendants to explore potential plasma biomarkers. Furthermore, the dose-response relationship was also identified. A total of 144 workers, including 96 petrol fillers and 48 cashiers, participated in the study. Ambient concentrations of benzene, toluene, ethylbenzene, and xylene (BTEX) and Mn were monitored at nine filling stations. During the measuring process, the individual cumulative exposure index was calculated. Plasma oxidative stress and Hsp70 levels were also analysed using enzyme-linked immunosorbent assay. The BTEX time-weighted average in office areas was significantly lower than in refuelling areas ( p < 0.05). In refuelling areas, the content of Mn ranged from 6.44 μg/m(3) to 127.34 μg/m(3), which was much higher than that in office areas (3.16-7.22 μg/m(3); p < 0.05). Exposed workers had significantly different plasma oxidative stress indicators compared with the control group, respectively: superoxide dismutase (SOD), 39.18 ± 6.05 U/mL versus 52.8...Continue Reading

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Citations

Mar 25, 2017·Molecular Medicine Reports·Chiara CostaConcettina Fenga
Mar 17, 2020·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Shoresh BarkhordariRoya Kelishadi
May 19, 2019·Environmental Science and Pollution Research International·Zahed AhmadiMohammad Hadi Nematollahi

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Methods Mentioned

BETA
enzyme-linked immunosorbent assay
MDA

Software Mentioned

SPSS

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