Increased oxidative stress from early pregnancy in women who develop preeclampsia

Clinical and Experimental Hypertension : CHE
Vandita D'SouzaSadhana Joshi

Abstract

Preeclampsia (PE) is a pregnancy-specific disorder, defined as new onset of maternal hypertension and proteinuria after 20 weeks of gestation. Our earlier study has shown increased maternal oxidative stress at delivery to be associated with poor birth outcome in PE. However, these results were observed when the pathology had progressed and may have been secondary to the effects of the disorder. To understand the role of antioxidant defense mechanisms in PE right from early pregnancy, in this prospective study, we measured malondialdehyde (MDA), superoxide dismutase (SOD), glutathione peroxidase (GPx) and glutathione (GSH) concentrations in maternal blood at 3 time-points of gestation [16-20 weeks (T1), 26-30 weeks (T2), at delivery (T3)] and in cord blood. Gene expression of SOD and GPx and protein levels of endothelial nitric oxide synthase (eNOS) enzyme were also analyzed in the placenta. MDA levels were higher at T1 (p < 0.01) and T2 (p < 0.01) in women with PE as compared with control. GPx levels were higher at T3 (p < 0.05) while SOD levels were lower at T2 (p < 0.05), T3 (p < 0.01) and in cord (p < 0.01) in PE. GSH levels at T1 (p < 0.05) and expression of GPx in the placenta were lower in PE as compared with control. In ...Continue Reading

References

Sep 1, 1995·British Journal of Obstetrics and Gynaecology·N H MorrisP J Steer
Dec 27, 1996·European Journal of Obstetrics, Gynecology, and Reproductive Biology·G LoverroL Selvaggi
Jul 1, 1997·Clinical Science·S P BrenneckeR G King
Dec 31, 1997·The Journal of Clinical Investigation·D G Harrison
Apr 17, 1999·European Journal of Obstetrics, Gynecology, and Reproductive Biology·M F KnapenE A Steegers
Jul 6, 2000·FEBS Letters·T Finkel
Mar 9, 2002·Current Hypertension Reports·Christopher S Wilcox
May 6, 2003·The Journal of Nutrition·Esther Casanueva, Fernando E Viteri
Jun 5, 2003·Hypertension·Ayako MakinoAllen W Cowley
Jul 17, 2004·Free Radical Biology & Medicine·Elisa LlurbaCarmen Dominguez
Aug 2, 2005·Nutrition, Metabolism, and Cardiovascular Diseases : NMCD·Daniele Del RioNicoletta Pellegrini
Apr 11, 2006·Clinical Biochemistry·Carole B RudraMichelle A Williams
May 30, 2006·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·J B SharmaS Mittal
Nov 6, 2007·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·Savita MehendaleSadhana Joshi
Jun 24, 2008·Journal of Obstetrics and Gynaecology : the Journal of the Institute of Obstetrics and Gynaecology·E AnastasakisA Antsaklis
Jun 17, 2009·Seminars in Cell & Developmental Biology·R DumollardK Swann
Sep 8, 2009·American Journal of Obstetrics and Gynecology·Chun S WuJørn Olsen
Mar 13, 2010·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Asmita V KulkarniSadhana R Joshi
Jul 6, 2010·The International Journal of Biochemistry & Cell Biology·Kaïs H Al-GuboryCatherine Garrel
Jul 27, 2010·Free Radical Biology & Medicine·Phyllis A Dennery
Aug 20, 2010·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Asmita KulkarniSadhana Joshi
Feb 24, 2011·Archives of Gynecology and Obstetrics·Habibe GencOnur Güralp
May 27, 2011·The American Journal of Clinical Nutrition·Lucilla PostonLucy C Chappell
May 9, 2012·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Reena NegiHari D Khanna
Mar 1, 2007·Indian Journal of Clinical Biochemistry : IJCB·S B PatilSheela M Kodliwadmath
Feb 2, 2013·Journal of Obstetrics and Gynaecology of India·Brahmarshi DasHarendra Nath Das
Apr 4, 2013·Biomarkers in Medicine·Imran A SiddiquiWaleed Tamimi
Apr 11, 2014·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Akriti S SahaySadhana R Joshi
Jul 6, 2014·Journal of Immunology Research·Alicia Martínez-VareaAntonio Pellicer
Sep 10, 2014·Tissue & Cell·Murat CanIlker Arikan
Nov 5, 2014·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Suchitra RoySadhana Joshi

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Citations

Aug 9, 2016·Revista Portuguesa De Cardiologia : Orgão Oficial Da Sociedade Portuguesa De Cardiologia = Portuguese Journal of Cardiology : an Official Journal of the Portuguese Society of Cardiology·Jorge Polónia
Oct 11, 2016·Prostaglandins, Leukotrienes, and Essential Fatty Acids·G E Leghi, B S Muhlhausler
Aug 31, 2016·Scientific Reports·Polina A VishnyakovaGennady T Sukhikh
Feb 9, 2017·Clinical Nutrition Research·Mahdiyeh SheikhiZamzam Paknahad
Aug 24, 2018·Biology of Reproduction·Hamid-Reza Kohan-GhadrSascha Drewlo
May 28, 2019·Fetal and Pediatric Pathology·Angelin Jeba Malar AbrahamSajini Elizabeth Jacob
May 2, 2018·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Jinjin LiPhilip N Baker
Mar 7, 2020·Journal of Cellular and Molecular Medicine·Miguel A OrtegaNatalio García-Honduvilla
Aug 25, 2019·BMC Pregnancy and Childbirth·Nisha S WadhwaniSadhana R Joshi
Mar 8, 2019·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Mayara Caldeira-DiasValéria C Sandrim
May 26, 2017·Microcirculation : the Official Journal of the Microcirculatory Society, Inc·Karine Ferreira AgraJoão Guilherme Bezerra Alves
Jul 1, 2020·Biomolecules·Manoj Kumar JenaNihar Ranjan Nayak
Jan 8, 2021·Hypertension in Pregnancy : Official Journal of the International Society for the Study of Hypertension in Pregnancy·Aditi A GodhamgaonkarSadhana R Joshi
Oct 7, 2019·Pregnancy Hypertension·Iman M AhmadTiffany A Moore
Sep 12, 2020·Biochimica Et Biophysica Acta. Molecular Basis of Disease·Reinaldo MarínLuis Sobrevia
Mar 3, 2020·Toxicology Letters·Ali Mustafa MohammedKirsi Vähäkangas
May 30, 2020·Reproductive Biomedicine Online·Rong LiJie Qiao
Apr 16, 2021·Oxidative Medicine and Cellular Longevity·Meihe LiHuimin Dang
May 29, 2021·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Liping HuangXiaojing Yue

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