Increased oxygen free radical production during pregnancy may impair vascular reactivity in preeclamptic women

Hypertension Research : Official Journal of the Japanese Society of Hypertension
Kazushi WatanabeAkihiko Wakatsuki

Abstract

To determine whether enhanced oxidative stress during pregnancy impairs vascular endothelial function and improves after delivery in preeclamptic women, we measured serum parameters of oxidative stress and endothelial function during pregnancy and 1 month after delivery in women with or without preeclampsia. We evaluated 18 participants with uncomplicated pregnancies, 11 with mild preeclampsia and 13 with severe preeclampsia. The plasma concentrations of reactive oxygen metabolite derivatives (d-ROMs) were measured, and the biological antioxidant potential (BAP) was determined to evaluate the oxygen free radicals and antioxidants, respectively. Flow-mediated vasodilation (FMD) was also assessed as a marker of endothelial function. FMD was decreased significantly in both preeclamptic groups compared with control during pregnancy. FMD did not change after delivery in the control group, but it significantly increased after delivery in both the mildly and severely preeclamptic groups, nearing control levels 1 month after delivery (mild, 6.5±3.6-9.0±3.5%; severe, 4.3±3.3-9.7±2.6%). No changes in d-ROM concentrations were observed in the control group; however, the concentrations in both the mildly and severely preeclamptic groups si...Continue Reading

References

Sep 27, 2013·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Toshitaka MoriAkihiko Wakatsuki
Mar 22, 2014·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Satoshi MorimotoAtsuhiro Ichihara
Oct 23, 2015·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Ploynin Puttapitakpong, Vorapong Phupong
Dec 3, 2014·Pediatrics International : Official Journal of the Japan Pediatric Society·Idris MehmetogluRahmi Ors
Jul 16, 2014·Hypertension in Pregnancy : Official Journal of the International Society for the Study of Hypertension in Pregnancy·Jyothi M P D'souzaNeevan D'souza
Mar 13, 2015·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Xiaoying Jiang, Qilan Ning
Feb 27, 2015·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Attila MolvarecJános Rigó
Sep 24, 2015·PloS One·Jossimara PolettiniRamkumar Menon
Jun 9, 2017·Journal of Atherosclerosis and Thrombosis·Takeshi MitsuhashiKen-Ichi Aihara
Apr 4, 2017·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Atsumi YoshidaAkihiko Wakatsuki
Apr 6, 2018·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Kanako BokudaAtsuhiro Ichihara
May 2, 2018·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Jinjin LiPhilip N Baker
Nov 12, 2014·Menopause : the Journal of the North American Menopause Society·Kazushi WatanabeIchiro Miyano
Apr 16, 2019·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Yuki OwakiAkihiko Wakatsuki
Sep 21, 2018·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Hisaaki KobayashiAkihiro Yoshino
Aug 12, 2017·Clinical Science·Rachel J SkowMargie H Davenport

Citations

Dec 1, 1991·American Journal of Obstetrics and Gynecology·S J WisdomJ J Walker
Nov 1, 1989·American Journal of Obstetrics and Gynecology·J M RobertsM K McLaughlin
Oct 1, 1989·American Journal of Obstetrics and Gynecology·C A HubelM K McLaughlin
Mar 29, 2001·Obstetrics and Gynecology·A P MacKayH K Atrash
Jul 28, 2001·The American Journal of Cardiology·R A Vogel
Oct 9, 2007·Journal of Hypertension·Rangeen Rafik HamadKatarina Bremme
Apr 1, 2008·Molecular and Cellular Biochemistry·Gurjit KaurRajendra Prasad
Jan 16, 2010·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Toshitaka MoriA Fujimaki
Jul 4, 2012·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Kazushi WatanabeAkihiko Wakatsuki

Related Concepts

Muscle, Smooth, Vascular
Derivatives
Blood Vessel
Diastolic Blood Pressure
Antioxidant Effect
Antioxidants
Free Radicals
Doppler Ultrasound Imaging
Oxidative Stress
Oxidative Stress Analysis

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Sexual Dimorphism in Neurodegeneration

There exist sex differences in neurodevelopmental and neurodegenerative disorders. For instance, multiple sclerosis is more common in women, whereas Parkinson’s disease is more common in men. Here is the latest research on sexual dimorphism in neurodegeneration

HLA Genetic Variation

HLA genetic variation has been found to confer risk for a wide variety of diseases. Identifying these associations and understanding their molecular mechanisms is ongoing and holds promise for the development of therapeutics. Find the latest research on HLA genetic variation here.

Super-resolution Microscopy

Super-resolution microscopy is the term commonly given to fluorescence microscopy techniques with resolutions that are not limited by the diffraction of light. Here are the latest discoveries pertaining to super-resolution microscopy.

Genetic Screens in iPSC-derived Brain Cells

Genetic screening is a critical tool that can be employed to define and understand gene function and interaction. This feed focuses on genetic screens conducted using induced pluripotent stem cell (iPSC)-derived brain cells.

Brain Lower Grade Glioma

Low grade gliomas in the brain form from oligodendrocytes and astrocytes and are the slowest-growing glioma in adults. Discover the latest research on these brain tumors here.

CD4/CD8 Signaling

Cluster of differentiation 4 and 8 (CD8 and CD8) are glycoproteins founds on the surface of immune cells. Here is the latest research on their role in cell signaling pathways.

Alignment-free Sequence Analysis Tools

Alignment-free sequence analyses have been applied to problems ranging from whole-genome phylogeny to the classification of protein families, identification of horizontally transferred genes, and detection of recombined sequences. Here is the latest research.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Related Papers

The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians
Kazushi WatanabeAkihiko Wakatsuki
Hypertension Research : Official Journal of the Japanese Society of Hypertension
Toshitaka MoriAkihiko Wakatsuki
The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians
Chiharu KimuraAkihiko Wakatsuki
Oxidative Medicine and Cellular Longevity
Fumiko NagatomoAkihiko Ishihara
© 2020 Meta ULC. All rights reserved