Increased palatable food intake and response to food cues in intrauterine growth-restricted rats are related to tyrosine hydroxylase content in the orbitofrontal cortex and nucleus accumbens

Behavioural Brain Research
Márcio Bonesso AlvesP P Silveira

Abstract

Intrauterine growth restriction (IUGR) is associated with altered food preferences, which may contribute to increased risk of obesity. We evaluated the effects of IUGR on attention to a palatable food cue, as well as tyrosine hydroxylase (TH) content in the orbitofrontal cortex (OFC) and nucleus accumbens (NAcc) in response to sweet food intake. From day 10 of gestation and through lactation, Sprague-Dawley rats received either an ad libitum (Adlib) or a 50% food-restricted (FR) diet. At birth, pups were cross-fostered, generating four groups (gestation/lactation): Adlib/Adlib (control), FR/Adlib (intrauterine growth-restricted), Adlib/FR, and FR/FR. Adult attention to palatable food cues was measured using the Attentional Set-Shifting Task (ASST), which uses a sweet pellet as reward. TH content in the OFC and NAcc was measured at baseline and in response to palatable food intake. At 90 days of age, FR/Adlib males ate more sweet food than controls, without differences in females. However, when compared to Controls, FR/Adlib females needed fewer trials to reach criterion in the ASST (p=0.04) and exhibited increased TH content in the OFC in response to sweet food (p=0.03). In the NAcc, there was a differential response of TH cont...Continue Reading

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Citations

Sep 20, 2015·Early Human Development·Cláudia Lopes BragaPatrícia Pelufo Silveira
Mar 26, 2016·Frontiers in Physiology·Amanda N Sferruzzi-Perri, Emily J Camm
Sep 29, 2015·Journal of Developmental Origins of Health and Disease·R Dalle MolleP P Silveira
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May 18, 2018·The British Journal of Nutrition·Adrianne R BischoffLaurette Dube
Sep 15, 2020·Brain Imaging and Behavior·Helena AlicartThomas F Münte
Sep 14, 2018·Scientific Reports·Patrícia P SilveiraMichael J Meaney
Oct 15, 2021·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Sharon M Kolk, Pasko Rakic

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