Increased particulate phosphodiesterase 4 in the prefrontal cortex supports 5-HT4 receptor-induced improvement of object recognition memory in the rat.

Psychopharmacology
Guénaëlle LevalletFrançois Dauphin

Abstract

Serotonin receptors (5-HT4Rs) are critical to both short-term and long-term memory processes. These receptors mainly trigger the cyclic adenosine monophosphate (cAMP)/protein kinase A signaling pathway, which is regulated by cAMP phosphodiesterases (PDEs). We investigated the mechanisms underlying the effect of the selective activation of 5-HT4R on information acquisition in an object recognition memory task and the putative regulation of PDE. The effect of RS 67333 (1 mg/kg, intraperitoneally [i.p.], injected 30 min before the sample phase) was examined at different delay intervals in an object recognition task in Sprague-Dawley rats. After the testing trial, PDE activity of brain regions implicated in this task was assayed. RS 67333-treated rats spent more time exploring the novel object after a 15-min (P < 0.001) or 4-h delay (P < 0.01) but not after a 24-h delay, whereas control animals showed no preference for the novel object for delays greater than 15 min. We characterized the specific patterns and kinetic properties of PDE in the prefrontal and perirhinal cortices as well as in the hippocampus. We demonstrated that particulate PDE activities increase in both the prefrontal cortex and hippocampus following 5-HT4R stimula...Continue Reading

References

Dec 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·C N ChenR L Davis
Nov 1, 1988·Behavioural Brain Research·A Ennaceur, J Delacour
Jan 19, 1971·Biochemistry·W J Thompson, M M Appleman
Jun 1, 1995·Journal of Neuroscience Research·P EngelsH Lübbert
May 1, 1996·Brain Research. Molecular Brain Research·Y IwahashiS Inagaki
Nov 26, 1996·Proceedings of the National Academy of Sciences of the United States of America·C H BaileyE R Kandel
Dec 31, 1996·Brain Research. Molecular Brain Research·M T VilaróG Mengod
Mar 1, 1997·Pharmacology, Biochemistry, and Behavior·A Meneses, E Hong
Apr 1, 1997·Neuropharmacology·S LettyG Rondouin
Apr 1, 1997·Neuropharmacology·E Marchetti-GauthierB Soumireu-Mourat
Aug 1, 1997·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·R BernabeuJ H Medina
Oct 24, 1998·The European Journal of Neuroscience·A Parker, D Gaffan
Dec 9, 1998·Proceedings of the National Academy of Sciences of the United States of America·M BaradE Kandel
Feb 12, 1999·Brain Research. Developmental Brain Research·K ZhangJ M O'Donnell
May 26, 1999·Pharmacology, Biochemistry, and Behavior·J M O'Donnell, S Frith
Sep 7, 2001·Neuropharmacology·V LelongM Boulouard
Mar 13, 2002·Pharmacology, Biochemistry, and Behavior·Daniel HoyerGraeme R Martin
Jul 20, 2002·The Journal of Pharmacology and Experimental Therapeutics·Paul C MoserBernard Scatton
Dec 21, 2002·The Journal of Biological Chemistry·Marco ContiCatherine Jin

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Citations

May 2, 2013·Pharmacology & Therapeutics·Jennifer M Loftis, Marilyn Huckans
Jan 17, 2014·Experimental Brain Research·Mohammad SeyedabadiReza Rahimian
Jun 3, 2014·Psychiatric Genetics·Amaia HervásMaría J Arranz
Feb 15, 2011·Pharmacology, Biochemistry, and Behavior·Alvin V TerryScott J Webster
Feb 24, 2011·Current Opinion in Pharmacology·Joël BockaertAline Dumuis
Jan 2, 2010·Behavioural Brain Research·Trisha A JenkinsStephen J Cooper
Jul 19, 2015·Behavioural Brain Research·Anne QuiedevilleValentine Bouet
Jan 22, 2014·Neurobiology of Learning and Memory·S AkkermanJ Prickaerts
Mar 19, 2013·Progress in Neuro-psychopharmacology & Biological Psychiatry·Shu Yan YuShuanglian Wang
Aug 23, 2011·Neuropharmacology·Joshua S RodeferSamuel J Eckrich
Jun 1, 2011·Neurobiology of Learning and Memory·Edwin Castiblanco-PiñerosFernando P Cardenas
Jun 17, 2014·Behavioural Brain Research·Nikolaos Pitsikas
Jun 16, 2016·Frontiers in Neuroscience·Mohammad A KhanfarHolger Stark
May 27, 2014·Journal of Chemical Information and Modeling·Alban LepailleurSylvain Rault
Oct 28, 2016·Behavioural Brain Research·Mohammad NasehiMohammad-Reza Zarrindast
Oct 17, 2019·Psychological Medicine·Susannah E MurphyCatherine J Harmer
Jun 15, 2016·Journal of Psychopharmacology·Mohammad NasehiMohammad-Reza Zarrindast
Apr 4, 2020·Psychological Medicine·Susannah E MurphyCatherine J Harmer
Aug 27, 2014·Proceedings of the National Academy of Sciences of the United States of America·Cédric LecouteyPatrick Dallemagne
Oct 31, 2020·Oxidative Medicine and Cellular Longevity·Min XieShihong Chen
Jan 27, 2017·Translational Neuroscience·Dubravka Švob ŠtracDorotea Mück-Šeler

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