PMID: 8586130Oct 1, 1995Paper

Increased peak flow variability in children with asymptomatic hyperresponsiveness

The European Respiratory Journal
P G GibsonF E Hargreave

Abstract

The relevance of increased methacholine airway responsiveness detected in children with no current or past symptoms of asthma is not known. We wished to determine whether the presence of airway hyperresponsiveness in asymptomatic children is also associated with abnormal variability of peak expiratory flow (PEF). In 12 asymptomatic children with methacholine hyperresponsiveness, we examined the diurnal variation of peak expiratory flow (PEF) and response to inhaled bronchodilator. Twelve asthmatic children with a comparable range of methacholine hyperresponsiveness, and 12 normal children without methacholine responsiveness, were used as positive and negative controls. The children were aged 11 (range 9-14) yrs. The mean diurnal variation of PEF in those children with asymptomatic hyperresponsiveness was increased at 9.3%, to a degree comparable to the symptomatic asthmatic children (10.7%), and greater than the normal children (5.7%). Methacholine stimulated airway constriction was associated with symptoms in subjects from each group, indicating that the children were capable of perceiving airway constriction. We conclude that asymptomatic children with methacholine airway hyperresponsiveness have other evidence of mild variab...Continue Reading

Citations

Sep 2, 1998·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·V GutiérrezE González
Mar 12, 1998·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·L PrietoI Inchaurraga
Jun 1, 1997·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·S D CrowtherJ Morley
Aug 1, 1997·American Journal of Respiratory and Critical Care Medicine·C Laprise, L P Boulet
Oct 6, 1997·American Journal of Respiratory and Critical Care Medicine·K L TimonenB Brunekreef
Jan 30, 2003·American Journal of Respiratory and Critical Care Medicine·Louis-Philippe Boulet
Aug 5, 2005·Environmental Health Perspectives·Toby C LewisYolanda Hill
Aug 20, 2003·Respiratory Medicine·Hélène TurcotteLouis-Philippe Boulet
Jun 14, 2005·Respiratory Medicine·Louis-Philippe BouletMichel Laviolette
Apr 2, 2005·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·Young Yull KohChang Keun Kim

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