Increased perfusion in normal appearing white matter in high inflammatory multiple sclerosis patients

PloS One
Maxim BesterSusanne Siemonsen

Abstract

Although cerebral perfusion alterations have long been acknowledged in multiple sclerosis (MS), the relationship between measurable perfusion changes and the status of highly active MS has not been examined. We hypothesized that alteration of perfusion can be detected in normal appearing white matter and is increased in high inflammatory patients. Thirty-three patients with relapsing-remitting MS underwent four monthly 3T MRI scans including dynamic susceptibility contrast perfusion-weighted MRI. Cerebral blood flow (CBF) and cerebral blood volume (CBV) were measured in normal appearing white matter. Patients were stratified in a high- and low-inflammatory group according to the number of new contrast enhancing lesions. Thirteen patients were classified as high-inflammatory. Compared to low-inflammatory patients, the high-inflammatory group demonstrated significantly higher CBV (p = 0.001) and CBF (p = 0.014) values. A mixed model analysis to assess independent variables associated with CBV and CBF revealed that white matter lesion load and atrophy measurements had no significant influence on CBF and CBV. This work provides evidence that high inflammatory lesion load is associated with increased CBV and CBF, underlining the rol...Continue Reading

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Methods Mentioned

BETA
imaging technique

Software Mentioned

STATA
SIENAX
AnToNIa
FSL
Analyze

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