Increased peripheral benzodiazepine receptors in arterial plaque of patients with atherosclerosis: an autoradiographic study with [(3)H]PK 11195

Atherosclerosis
Yota FujimuraMasahiro Fujita

Abstract

Inflammation in atherosclerotic plaques makes them unstable and can cause thrombosis. Therefore, it is important to detect macrophage activity for clinical management of atherosclerosis. Peripheral benzodiazepine receptor (PBR) is expressed in various tissue and organs including macrophages. In this study, we tested whether inflammation characterized by macrophage infiltration can be detected by PBR binding. Six patients diagnosed as carotid atherosclerosis underwent endarterectomy. Using the fresh frozen sections, presence of PBRs and macrophages was examined by in vitro autoradiography using [(3)H]PK 11195 and immunohistochemical staining of CD68, respectively. All sections showed specific binding of [(3)H]PK 11195, and the staining with CD68 indicating macrophage infiltration. Density and distribution of PBR detected by [(3)H]PK 11195 autoradiography were consistent with those of the immunohistochemical staining. In conclusion, this study demonstrated that macrophage and inflammatory activity in atherosclerotic plaque can be imaged specifically by the binding of PBR indicating future application of PET imaging for PBR.

References

Nov 27, 1984·European Journal of Pharmacology·F ZavalaM Lenfant
Dec 1, 1995·Atherosclerosis·A P Schroeder, E Falk
Oct 1, 1996·Current Opinion in Lipidology·P LibbyR T Lee

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Citations

Aug 17, 2012·Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging·Romina MizrahiPeter M Bloomfield
Oct 18, 2012·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Myra S CockerRob S B Beanlands
Jul 3, 2010·Nature Reviews. Rheumatology·Justin C Mason
Apr 18, 2012·European Heart Journal·Paolo G CamiciPeter Libby
Mar 24, 2009·Arteriosclerosis, Thrombosis, and Vascular Biology·James H F RuddZahi A Fayad
Sep 12, 2013·Future Cardiology·William S A JenkinsMarc R Dweck
Jul 10, 2013·Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging·Frederick M LarteyBilly W Loo
Jan 10, 2014·Journal of Cardiovascular Translational Research·DeLisa FairweatherTomás R Guilarte
Jan 14, 2011·Annual Review of Medicine·D R J OwenZ A Fayad
Dec 16, 2011·Journal of Cardiovascular Translational Research·Leonarda GaliutoFilippo Crea
Dec 20, 2012·Oxidative Medicine and Cellular Longevity·Xiaolong QiJunjie Xiao
Apr 14, 2015·Analytical Sciences : the International Journal of the Japan Society for Analytical Chemistry·Sung-Jin ParkYoung-Tae Chang
Jul 22, 2015·Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging·Jinzi ZhengRaphaël Boisgard
May 16, 2009·Journal of the Formosan Medical Association = Taiwan Yi Zhi·Lin-Chau ChangWei-Shiung Yang
Mar 5, 2011·European Journal of Radiology·José Leite Gondim Cavalcanti FilhoLea Mirian Barbosa da Fonseca
Jan 13, 2011·Thrombosis and Haemostasis·T QuillardP Libby
Jan 22, 2015·Future Cardiology·Jason M TarkinJames H F Rudd
Aug 14, 2010·Journal of the American College of Cardiology·Francesca PugliesePaolo G Camici
Apr 25, 2016·Current Atherosclerosis Reports·Nicholas R EvansJames H F Rudd
May 27, 2016·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Sanna HellbergAntti Saraste
Sep 30, 2016·Thrombosis and Haemostasis·Luca LiberaleFederico Carbone
Feb 10, 2017·Rheumatology·Nehal NarayanPeter C Taylor
Jun 11, 2014·Nature Reviews. Cardiology·Jason M TarkinJames H F Rudd
Jul 9, 2016·Circulation Research·Marc R DweckZahi A Fayad
Jul 16, 2010·Journal of Cellular and Molecular Medicine·Heather M Wilson
Sep 2, 2016·European Respiratory Review : an Official Journal of the European Respiratory Society·Selene CapitanioClaudio Rossetti
Oct 7, 2017·Nature Reviews. Neurology·Nicholas R EvansElizabeth A Warburton
Jun 25, 2019·Cardiovascular Research·Mark G MacAskillAdriana A S Tavares
Sep 14, 2019·British Journal of Pharmacology·Rouchelle S SriranjanJames H F Rudd
Feb 23, 2020·The Quarterly Journal of Nuclear Medicine and Molecular Imaging : Official Publication of the Italian Association of Nuclear Medicine (AIMN) [and] the International Association of Radiopharmacology (IAR), [and] Section of the Society of Radiopharmaceutica·Gyu S HeoYongjian Liu
Jun 14, 2019·Arteriosclerosis, Thrombosis, and Vascular Biology·Tariq E FarrahNeeraj Dhaun
Feb 10, 2021·Biomedicines·Meredith A JonesLacey R McNally
Dec 15, 2010·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Frederic LamareOrnella E Rimoldi
Apr 17, 2010·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Wilfredo Ayala-LópezPhilip S Low

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