Increased Peripheral Interleukin 10 Relate to White Matter Integrity in Schizophrenia

Frontiers in Neuroscience
Gui FuSu Lui

Abstract

Background: Schizophrenia is characterized by the disruption of microstructural white matter (WM) integrity, while the pathogenesis remains unclear. Inflammation has been associated with the WM pathology in schizophrenia. Interleukin 10 (IL-10) has been proven to be related to schizophrenia in both animal and human models. The aim of this study was to explore whether peripheral IL-10 was associated with microstructural WM integrity in schizophrenia. Methods: A total of 47 patients with schizophrenia (SZ) and 49 healthy controls (HC) underwent diffusion tensor imaging and venous blood sampling. Tract-based spatial statistics was conducted to explore the differences in fractional anisotropy (FA), radial diffusivity (RD), mean diffusivity (MD), and axial diffusivity (AD) between patients and controls. A quantitative chemiluminescence assay was performed to measure peripheral IL-10 levels. General linear regression analysis using a stepwise method was applied to examine the relationship between peripheral IL-10 and diffusion measures. Results: Compared with the HC, peripheral IL-10 levels were higher and a significant reduction of FA and AD, and increase of RD and MD were observed in SZ (corrected p < 0.05). A regression analysis r...Continue Reading

References

May 3, 2005·NeuroImage·Sheng-Kwei SongRegina C Armstrong
Apr 21, 2006·NeuroImage·Stephen M SmithTimothy E J Behrens
Nov 29, 2007·Journal of the Peripheral Nervous System : JPNS·Simon AtkinsPeter P Robinson
May 23, 2008·Schizophrenia Research·Richard S E KeefeKirsten Hawkins
Oct 28, 2008·Brain : a Journal of Neurology·R A DineenD P Auer
Jan 14, 2009·Progress in Neuro-psychopharmacology & Biological Psychiatry·Haruhiko SuginoYoshinori Marunaka
Sep 25, 2009·Cortex; a Journal Devoted to the Study of the Nervous System and Behavior·Juan MartinoHugues Duffau
Oct 6, 2011·Revista brasileira de psiquiatria : orgão oficial da Associação Brasileira de Psiquiatria, Asociación Psiquiátrica de la América Latina·Mauricio KunzClarissa Severino Gama
Sep 19, 2012·Cytokine & Growth Factor Reviews·Pía M VidalSven Hendrix
Jan 15, 2013·Progress in Neuro-psychopharmacology & Biological Psychiatry·Thomas Frodl, Francesco Amico
Jan 18, 2013·Current Opinion in Psychiatry·Jennifer FitzsimmonsMartha E Shenton
Jul 9, 2013·Biological Psychiatry·Samantha J FungCynthia Shannon Weickert
Aug 6, 2013·Archives of Clinical Neuropsychology : the Official Journal of the National Academy of Neuropsychologists·Goi Khia EngRichard S E Keefe
Nov 5, 2013·Brain Structure & Function·Branislava Ćurčić-BlakeAndré Aleman
Feb 18, 2014·NeuroImage·Anderson M WinklerThomas E Nichols
Jun 21, 2014·Schizophrenia Research·Souhel Najjar, Daniel M Pearlman
Dec 3, 2014·Biological Psychiatry·Qiyong Gong, Yong He
Apr 2, 2015·Psychoneuroendocrinology·Milica BorovcaninMiodrag L Lukic
Apr 4, 2015·PloS One·Birk Diedenhofen, Jochen Musch
Jun 4, 2015·Psychopharmacology·Golam M Khandaker, Robert Dantzer
Dec 18, 2015·Journal of Affective Disorders·G FondUNKNOWN FACE-SZ (FondaMental Academic Centers of Expertise for Schizophrenia) group
Jan 18, 2016·Psychiatry Research. Neuroimaging·Sung-Jae LeeSang-Hyuk Lee
Jun 3, 2016·Journal of Affective Disorders·Francesco BenedettiHemmo A Drexhage
Jun 23, 2016·American Journal of Obstetrics and Gynecology·Rebecca J BaerLaura L Jelliffe-Pawlowski
Jul 14, 2016·NeuroImage. Clinical·Petra V ViherSebastian Walther
Nov 15, 2016·The American Journal of Geriatric Psychiatry : Official Journal of the American Association for Geriatric Psychiatry·Ellen E LeeDilip V Jeste

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Citations

Jul 10, 2020·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·Felix L NägeleChristoph Mulert
Jan 8, 2020·Frontiers in Psychiatry·Sara MomtazmaneshNima Rezaei
Feb 11, 2020·Frontiers in Psychiatry·Jing QiShao-Qing Ju
Aug 17, 2021·Brain Communications·Anastasia LanquetinAnne-Lise Pitel

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Methods Mentioned

BETA
Assay

Software Mentioned

SPSS
FNIRT
FSL
MRIcron
R

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