Increased permeability occurs in rat ileum following induction of pan-colitis

Digestive Diseases and Sciences
N CuiR N Fedorak

Abstract

Acetic acid-induced pan colitis in rats leads not only to colonic injury but also to a bystander ileal injury, characterized by decreased fluid and electrolyte absorption without associated histological injury or infiltration of inflammatory cells. To examine the nature of this decreased ileal fluid and electrolyte absorption, we measured effect of acetic acid-induced pancolitis on ileal transmural sodium and chloride transport, as well as on ileal permeability to mannitol and inulin on mucosal sheets mounted in Ussing chambers. In addition, ileal tight junctional morphology was assessed by electron microscopy. In colitic animals, ileal serosal-to-mucosal sodium and chloride transmural fluxes were increased (P<0.05); compatible with the observed decrease in net fluid absorption. Mannitol and inulin ileal serosal-to-mucosal and mucosal-to-serosal ileal fluxes were similarly increased (P<0.05), suggesting that an increase in ileal permeability occurred during acetic acid-induced pancolitis. This increase in ileal permeability was not accompanied by changes in tight junctional ultrastructure. These results suggest that: (1) the decrease in ileal fluid and electrolyte absorption seen during acetic acid-induced rat pancolitis occurr...Continue Reading

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Citations

Jul 14, 1998·The Journal of Cell Biology·T S JouW J Nelson
Mar 21, 2006·Surgery·Payam SalehiThomas A Churchill
May 1, 1997·Placenta·F J LinR S Tuan
Nov 1, 2016·Journal of Crohn's & Colitis·Fadi H MouradNayef E Saade
Aug 17, 2004·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Toshiaki TsujimuraThomas A Churchill
Apr 16, 2004·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Payam SalehiThomas A Churchill
Jul 10, 2002·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·D OlsonT Churchill
Aug 27, 2005·American Journal of Physiology. Gastrointestinal and Liver Physiology·Fadi H MouradCamille F Nassar

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