Increased phosphorylation of the renal Na+-Cl- cotransporter in male kidney transplant recipient patients with hypertension: a prospective cohort

American Journal of Physiology. Renal Physiology
Lorena Rojas-VegaGerardo Gamba

Abstract

Evidence in rodents suggests that tacrolimus-induced posttransplant hypertension is due to upregulation of the thiazide-sensitive Na(+)-Cl(-) cotransporter NCC. Here, we analyzed whether a similar mechanism is involved in posttransplant hypertension in humans. From January 2013 to June 2014, all adult kidney transplant recipients receiving a kidney allograft were enrolled in a prospective cohort study. All patients received tacrolimus as part of the immunosuppressive therapy. Six months after surgery, we assessed general clinical and laboratory variables, tacrolimus trough blood levels, and ambulatory 24-h blood pressure monitoring. Urinary exosomes were extracted to perform Western blot analysis using total and phospho-NCC antibodies. A total of 52 patients, including 17 women and 35 men, were followed. At 6 mo after transplantation, of the 35 men, 17 developed hypertension and 18 remained normotensive, while high blood pressure was observed in only 3 of 17 women. The hypertensive patients were significantly older than the normotensive group; however, there were no significant differences in body weight, history of acute rejection, renal function, and tacrolimus trough levels. In urinary exosomes, hypertensive patients showed ...Continue Reading

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Citations

Nov 2, 2016·The Journal of Physiology·Eduardo R Argaiz, Gerardo Gamba
Dec 23, 2016·American Journal of Physiology. Renal Physiology·K I BlankensteinK Mutig
Oct 4, 2015·Journal of the American Society of Nephrology : JASN·Rebecca A LazelleDavid H Ellison
Feb 6, 2019·Proceedings of the National Academy of Sciences of the United States of America·Kenichi IshizawaShigeru Shibata
Feb 23, 2020·Frontiers in Pharmacology·Visith Thongboonkerd
Jun 17, 2016·Proceedings. Biological Sciences·Yi-Fang WangPung-Pung Hwang
May 17, 2017·Frontiers in Pediatrics·Olga Charnaya, Asha Moudgil
Oct 29, 2017·Cellular and Molecular Life Sciences : CMLS·Olga Moreno-GonzaloFrancisco Sanchez-Madrid
Apr 22, 2016·American Journal of Physiology. Renal Physiology·Silvana Bazúa-ValentiGerardo Gamba
Feb 2, 2021·Experimental Biology and Medicine·Zhi Z LiuChunyu Zeng

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