Increased placental apoptosis in intrauterine growth restriction

American Journal of Obstetrics and Gynecology
S C SmithE M Symonds

Abstract

Our purpose was to investigate a possible role for apoptosis in the pathophysiologic mechanisms of intrauterine growth restriction. Placental samples were obtained from 43 uncomplicated third-trimester pregnancies and from 26 pregnancies complicated by intrauterine growth restriction. The definition used to identify cases of intrauterine growth restriction depended on three criteria: clinical evidence of suboptimal growth, ultrasonographic evidence of deviation from an appropriate growth percentile, and individualized birth weight ratios <10th percentile. Light microscopy was used to quantify the incidence of apoptosis. Electron microscopy and TUNEL (terminal deoxynucleotidyl transferase-mediated deoxyuridine triphosphate nick end labeling) staining were used to confirm the occurrence of apoptosis. Quantification of apoptosis (medians and interquartile ranges) resulted in the following values: normal third trimester (n = 43) 0.14% of cells (0.08% to 0.20%) and intrauterine growth restriction third trimester (n = 26) 0.24% of cells (0.16% to 0.29%). The incidence of apoptosis was significantly higher in placentas from pregnancies with intrauterine growth restriction compared with normal third-trimester placentas (p < 0.01, Mann ...Continue Reading

References

Nov 1, 1978·The Journal of Pathology·C J Jones, H Fox
Nov 1, 1992·The Journal of Cell Biology·Y GavrieliS A Ben-Sasson
Jun 1, 1995·Archives of Histology and Cytology·M YasudaY Tsutsumi
Jan 1, 1995·British Journal of Obstetrics and Gynaecology·P N BakerB S Worthington
Nov 1, 1994·European Journal of Clinical Investigation·J Savill
Dec 1, 1993·Immunology Today·L M Schwartz, B A Osborne
Feb 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·L M SchwartzB A Osborne
Apr 1, 1993·British Journal of Obstetrics and Gynaecology·M A WilcoxC E Chilvers

❮ Previous
Next ❯

Citations

Jan 25, 2007·Reproduction : the Official Journal of the Society for the Study of Fertility·R T KilaniL J Guilbert
Nov 3, 2011·Reproduction : the Official Journal of the Society for the Study of Fertility·Mark S LongtineD Michael Nelson
Dec 11, 2013·Reproduction : the Official Journal of the Society for the Study of Fertility·M A CostaG Correia-da-Silva
Apr 29, 2014·Journal of Diabetes and Its Complications·Thomas R MageeLouiza Belkacemi
Mar 25, 2006·Molecular Human Reproduction·Frank A HillsJan J Brosens
Dec 4, 2003·Reproductive Biology and Endocrinology : RB&E·Gil Mor, Vikki M Abrahams
Feb 15, 2007·International Journal of Medical Sciences·Shin-ichi IshiokaTsuyoshi Saito
May 13, 2008·Environmental Health Perspectives·Hyunok ChoiFrederica P Perera
Dec 31, 2008·PloS One·Mariantonietta Di StefanoJosè Ramòn Fiore
Jul 28, 2010·The Journal of Clinical Endocrinology and Metabolism·E VasilopoulouS-Y Chan
Oct 26, 2010·Reproductive Biology and Endocrinology : RB&E·Gabriela F MeresmanJuan J Etchepareborda
Aug 4, 2011·Reproductive Biology and Endocrinology : RB&E·Haruki NishizawaYasuhiro Udagawa
Sep 16, 2011·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Louiza BelkacemiMichael G Ross
Jul 16, 2010·Journal of Perinatal Medicine·Sofia LiosiAriadne Malamitsi-Puchner
Dec 12, 2001·Molecular and Cellular Endocrinology·M C Sugden, M L Langdown
Feb 18, 2004·Journal of Reproductive Immunology·Rigmor AustgulenCatherine Craven
Jan 25, 2012·Journal of Toxicologic Pathology·Satoshi FurukawaIzumi Ogawa
May 30, 2001·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·C T ErelK Aydinli
Apr 20, 2005·Virchows Archiv : an International Journal of Pathology·Christopher Burke, Glenda Gobe
Jun 19, 2007·Apoptosis : an International Journal on Programmed Cell Death·Sarah J MollAlexander E P Heazell
Nov 6, 2010·Apoptosis : an International Journal on Programmed Cell Death·Alexander E P HeazellIan P Crocker
Jul 13, 2004·Histochemistry and Cell Biology·Leslie Myatt, Xiaolan Cui
Jul 27, 2007·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Quan-Hong SunYing Yang
May 16, 2006·Journal of Huazhong University of Science and Technology. Medical Sciences = Hua Zhong Ke Ji Da Xue Xue Bao. Yi Xue Ying De Wen Ban = Huazhong Keji Daxue Xuebao. Yixue Yingdewen Ban·Hui Gao, Li Zou
Jul 10, 2003·Clinical Biochemistry·Abdelaziz KharfiJean-Claude Forest
Jan 13, 2015·Nutrients·Song ZhangJanna L Morrison
Jan 1, 2013·Pregnancy Hypertension·Satya S PolavarapuChaur-Dong Hsu
May 23, 2012·Reproductive Toxicology·Bruno M FonsecaNatércia A Teixeira
Sep 6, 2011·Molecular and Cellular Endocrinology·Dave LanoixCathy Vaillancourt
Apr 7, 2009·Taiwanese Journal of Obstetrics & Gynecology·Graham J Burton, Carolyn J P Jones
Jan 17, 2009·Reproductive Biomedicine Online·Alexander E P HeazellIan P Crocker

❮ Previous
Next ❯

Related Concepts

Related Feeds

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

Related Papers

American Journal of Obstetrics and Gynecology
S C SmithE M Symonds
FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology
Steven K HuangMarc Peters-Golden
© 2021 Meta ULC. All rights reserved