Increased placental telomerase mRNA in hypertensive disorders of pregnancy.

Hypertension in Pregnancy : Official Journal of the International Society for the Study of Hypertension in Pregnancy
Ossie Geifman-HoltzmanDan A Liebermann

Abstract

We assessed hTERT mRNA levels in normal versus preeclamptic placental samples, examining hTERT expression levels in different clinical manifestations of hypertensive disorder of pregnancy. We performed a single-site, prospective case-control study of hTERT mRNA levels in placentas from term and preterm pregnancies with hypertensive disorders compared with unaffected pregnancies. Placental biopsies were collected from 61 patients (preeclamptic: 32; non-preeclamptic (control): 29). Total RNA from placenta was isolated and reversely transcribed to c-DNA. A probe-specific real-time quantitative PCR assay was employed to determine the relative expressional levels of hTERT mRNA levels in these placentas from both unaffected and affected pregnancies with different categories of hypertensive disorders including preeclampsia, severe preeclampsia, eclampsia and HELLP syndrome (Hemolysis, Elevated Liver function tests, Low Platelet). The average ratio of hTERT mRNA levels was 1.73 in the preeclamptic group and 1.02 for control group (p < 0.0001). The hTERT expression levels were elevated for each of the different categories of hypertensive disorders of pregnancy compared with control: HELLP syndrome 1.86, severe preeclampsia 1.81, eclamps...Continue Reading

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Citations

Sep 5, 2012·Journal of Obstetrics and Gynaecology : the Journal of the Institute of Obstetrics and Gynaecology·K TomsinW Gyselaers
Jan 18, 2018·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Sonja EntringerPathik D Wadhwa
May 5, 2018·American Journal of Reproductive Immunology : AJRI·Wendy FitzgeraldLeonid Margolis

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