Increased Plasma Adenosine Concentration in the Subacute Phase May Contribute to Attenuation of Left Ventricular Dilation in the Chronic Phase in Patients With Acute Myocardial Infarction

Circulation Journal : Official Journal of the Japanese Circulation Society
Masanori HatasaShinya Minatoguchi

Abstract

Changes in the plasma adenosine concentration and the effects on left ventricular (LV) function and remodeling in patients with acute myocardial infarction (AMI) remain unclear. Methods and Results: In 58 patients with AMI and 14 subjects without cardiac disease (controls), we measured the plasma adenosine concentration by LC-MS/MS. Blood samples were taken from the antecubital vein on days 0, 1, 7, and 14 after AMI, and from the controls on admission. Cardiac echocardiography was performed in the acute (within 7 days) and chronic (6 months) phases of AMI. There were no significant differences in the plasma adenosine concentrations among days 0 (211.5±150.2 nmol/L), 1 (192.7±141.3 nmol/L), 7 (218.8±154.1 nmol/L), and the controls (136.0±50.9 nmol/L). The plasma adenosine concentration increased significantly on day 14 (321.1±195.4 nmol/L) after AMI as compared with days 0, 1 and 7. AMI patients with a greater increase in the plasma adenosine concentration in the subacute phase showed an attenuation of LV dilation in the chronic phase. The plasma adenosine concentration in the acute phase did not affect the LV ejection fraction in the chronic phase. The plasma adenosine concentration significantly increased 14 days after AMI, wh...Continue Reading

References

Aug 1, 1993·The American Journal of Physiology·J D ThorntonJ M Downey
Oct 24, 1998·Cardiovascular Drugs and Therapy·M KitakazeM Hori
Aug 24, 2005·Current Controlled Trials in Cardiovascular Medicine·Aslan T TurerE Magnus Ohman
Dec 1, 2007·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Shoji SanadaMasatsugu Hori
Nov 13, 2015·Analytical Sciences : the International Journal of the Japan Society for Analytical Chemistry·Hiroya MurakamiBunji Uno
Mar 2, 2018·Circulation Journal : Official Journal of the Japanese Circulation Society·Yujiro KinomuraShinya Minatoguchi

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Citations

Jul 2, 2021·Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan·Bunji Uno

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