PMID: 589124Nov 12, 1977

Increased plasma adrenaline concentrations in benign essential hypertension

British Medical Journal
R Franco-MorselliP Meyer

Abstract

Plasma adrenaline, noradrenaline, and dopamine concentrations and plasma renin activity were measured in the supine position and after standing for 10 minutes in 14 patients with sustained benign essential hypertension and in five patients with labile hypertension. Results were compared with values obtained in 11 normotensive control subjects. In controls plasma noradrenaline concentrations increased with age, while plasma adrenaline values tended to decrease with age. No significant difference in mean plasma noradrenaline was found between hypertensive and control subjects, but plasma noradrenaline seemed slightly increased in a proportion of hypertensive patients aged less than 50. Plasma adrenaline was considerably raised in both supine and standing positions in eight patients with sustained hypertension and in two with labile hypertension. Dopamine concentrations and plasma renin activity were similar in all groups studied. The finding of significantly raised plasma adrenaline concentrations in a large proportion of hypertensive patients supports the hypothesis that the activity of the sympathetic nervous system is increased in essential hypertension. Measurement of plasma adrenaline seems to be a more sensitive index of th...Continue Reading

References

Apr 1, 1976·The Journal of Pharmacy and Pharmacology·B A Callingham, M Barrand
May 21, 1977·Lancet·P S SeverR D Tunbridge
Jan 27, 1977·The New England Journal of Medicine·C R LakeI J Kopin
Sep 10, 1976·European Journal of Clinical Investigation·N J ChristensenH L Frankel
Feb 1, 1976·Circulation Research·J de ChamplainM R van Ameringen
Oct 1, 1968·Japanese Circulation Journal·M OzakiK Okamoto
Sep 1, 1969·Circulation Research·J de ChamplainJ Axelrod
Jan 1, 1967·Circulation Research·J de ChamplainJ Axelrod
Aug 15, 1953·Journal of the American Medical Association·R H SMITHWICK, J E THOMPSON

Citations

Jan 1, 1991·Cardiovascular Drugs and Therapy·P A PhillipsC I Johnston
Dec 1, 1979·Irish Journal of Medical Science·G A Fitzgerald
Jan 1, 1989·Pharmacology & Therapeutics·C Bell
Mar 1, 1983·Journal of the Autonomic Nervous System·R H Johnson
Feb 1, 1985·Journal of the American College of Cardiology·L R KrakoffK Yeager
Apr 26, 1984·The New England Journal of Medicine·P ErneF R Bühler
Jan 1, 1983·Experimental Aging Research·N R Cutler, J E Hodes
Oct 1, 1993·British Journal of Obstetrics and Gynaecology·P M KyleC W Redman
Jan 6, 1979·British Medical Journal·R T JungW P James
Jan 1, 1980·Critical Reviews in Clinical Laboratory Sciences·M D Burke
Mar 1, 1994·Blood Pressure·L T Jablonskis, P R Howe
Jan 1, 1987·Clinical and Experimental Hypertension. Part A, Theory and Practice·C Bell
Jan 1, 1985·Clinical and Experimental Hypertension. Part A, Theory and Practice·V DeQuattro, R Hamad
Jan 1, 1989·Clinical and Experimental Hypertension. Part A, Theory and Practice·Y MiuraK Abe
Jan 1, 1984·Clinical and Experimental Hypertension. Part A, Theory and Practice·M J Rand, H Majewski
Jan 1, 1980·Clinical and Experimental Hypertension : CHE·M G ZieglerB R Brooks
Jan 1, 1980·Clinical and Experimental Hypertension : CHE·I J KopinI Yamaguchi
Sep 1, 1986·Scandinavian Journal of Clinical and Laboratory Investigation·S E KjeldsenP Leren
Jan 1, 1997·Kidney International·M G ZieglerB Kennedy
Nov 26, 2010·Immunology and Allergy Clinics of North America·Kathi L Heffner
Nov 4, 2000·The Journal of Physiology·D R Seals, M D Esler
Jul 1, 1989·Thrombosis Research·G D'AndreaA R Cananzi
Aug 1, 1984·Journal of the American Geriatrics Society·V Fiorica
Jan 1, 1980·British Journal of Clinical Pharmacology·P BarnesC A Hamilton
Dec 1, 1982·British Journal of Obstetrics and Gynaecology·P G NatrajanG C Lachelin
May 1, 1982·British Journal of Clinical Pharmacology·H H VincentM A Schalekamp
Jan 1, 1988·Annals of the New York Academy of Sciences·M KurosawaH Suzuki
Oct 1, 1980·European Journal of Clinical Investigation·G A FitzgeraldC T Dollery
Jun 1, 1988·Journal of Autonomic Pharmacology·K R Borkowski
Jun 1, 1981·British Journal of Obstetrics and Gynaecology·D A Davey, M F Macnab
Jan 1, 1980·British Journal of Pharmacology·H MajewskiD F Story
Sep 27, 2002·European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery·R Roncon-AlbuquerqueR Roncon-Albuquerque
Nov 1, 1982·Hypertension·O KuchelJ Genest
Jan 1, 1980·Hypertension·M G NichollsJ Greenhouse
May 1, 1995·Hypertension·S E KjeldsenS Julius
Jan 1, 1992·Hypertension·J S Floras
Oct 12, 2018·The Journal of Physiology·E N Bardsley, D J Paterson
Oct 1, 1986·Medicinal Research Reviews·H Majewski, M J Rand
Jan 1, 1987·Critical Reviews in Microbiology·I Brook
Jan 1, 1990·Annals of the New York Academy of Sciences·K R Borkowski
Jan 1, 1982·Acta Medica Scandinavica. Supplementum·K E Andersson
Feb 23, 2019·Frontiers in Endocrinology·Andreas YiallourisElizabeth O Johnson
Apr 1, 1986·Medicinal Research Reviews·Y Misu, T Kubo
Mar 1, 1981·Stroke; a Journal of Cerebral Circulation·M G MyersM J Sole
Dec 9, 2017·Current Medical Research and Opinion·Janusz SkrzypeckiMarcin Ufnal
Jan 31, 2002·Upsala Journal of Medical Sciences·A Elmasry
May 1, 2004·Circulation Journal : Official Journal of the Japanese Circulation Society·Kazuhide OginoChiaki Shigemasa
Nov 5, 2020·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·L M NisimuraL R Garzoni

Related Concepts

Intropin
Medihaler-Epi
Hypertensive Disease
Norepinephrine, (+, -)-Isomer
Preprorenin

Related Feeds

Blood Clotting Disorders

Thrombophilia includes conditions with increased tendency for excessive blood clotting. Blood clotting occurs when the body has insufficient amounts of specialized proteins that make blood clot and stop bleeding. Here is the latest research on blood clotting disorders.