PMID: 9165414Jun 1, 1997Paper

Increased plasma concentrations of brain natriuretic peptide in patients with acute lung injury

Journal of Critical Care
C MitakaK Amaha

Abstract

This study was performed to elucidate the pathophysiological role of brain natriuretic peptide (BNP) and atrial natriuretic peptide (ANP) in acute lung injury. We sequentially measured plasma concentrations of immunoreactive BNP and ANP in 10 patients (mean age, 63 years (with acute lung injury and compared those with hemodynamic parameters and pulmonary functions. Plasma concentrations of immunoreactive BNP and ANP were markedly elevated at entry into the study. Plasma BNP concentrations during the early course (3 days) showed significant (P < .01) positive correlations with systemic vascular resistance index (r = .708) and pulmonary vascular resistance index (r = .573), but a negative correlation with cardiac index (r = .608). Plasma ANP concentrations showed a significant (P < .05) positive correlation with pulmonary capillary wedge pressure (r = .398). Plasma BNP in 4 patients who died and 1 patient with acute renal failure remained elevated during the entire hospital length of stay (12 days). These findings suggest that circulating BNP plays an important role in acute lung injury along with ANP as a compensatory mechanism for cardiac dysfunction accompanied by increased systemic vascular resistance index and pulmonary vasc...Continue Reading

References

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Citations

Sep 9, 2005·Critical Care Medicine·Jason PhuaLee Kang Hoe
Jun 9, 2006·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·John M CostelloThomas P Green
Oct 8, 2004·Critical Care : the Official Journal of the Critical Care Forum·Rochus Witthaut
Aug 19, 2003·European Journal of Heart Failure·Denis Mariano-GoulartPierre-Olivier Kotzki
Jul 25, 2006·Annales Françaises D'anesthèsie Et De Rèanimation·S ThierryA Tenaillon
Oct 6, 2005·European Journal of Heart Failure·Micha MaederHans Rickli
Oct 1, 2008·Expert Opinion on Medical Diagnostics·Kevin JiangAlan S Maisel
Jan 22, 2002·Best Practice & Research. Clinical Endocrinology & Metabolism·E S Nylén, A A Alarifi
Nov 24, 1999·The Journal of Laboratory and Clinical Medicine·N ValliL Bordenave
Dec 7, 2007·Journal of Intensive Care Medicine·Emanuel P RiversManisha Loomba
Nov 6, 2010·European Journal of Heart Failure·Ursula KlaarHelmut Baumgartner
Apr 16, 2014·Journal of Cardiac Surgery·Satyajit SinghHimanshu Rai
Sep 17, 2020·Journal of Clinical Medicine·Sabato SorrentinoCiro Indolfi
Jan 4, 2001·Journal of Critical Care·J E Tanus-SantosH Moreno
Aug 31, 2021·Acta Cardiologica·Bert ZwaenepoelSofie Gevaert

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