Increased plasma dipeptidyl peptidase-4 activities are associated with high prevalence of subclinical atherosclerosis in Chinese patients with newly diagnosed type 2 diabetes: a cross-sectional study

Atherosclerosis
T P ZhengH B Liu

Abstract

Hyperglycemia, insulin resistance, dislipidemia, oxidative stress and inflammation are well-documented risk factors for subclinical atherosclerosis. Dipeptidyl peptidase-4(DPP4) is a newly identified adipokine related to these risk factors. Hence, we aimed to investigate the association between plasma DPP4 activities and subclinical atherosclerosis in type 2 diabetes. A total of 985 newly diagnosed type 2 diabetic subjects were studied. Plasma DPP4 activity, mannose 6-phosphate receptor (M6P-R), oxidative stress parameters, inflammatory markers and common carotid artery Intima-Media Thickness (c-IMT) were measured in all participants. Participants in the highest quartile of DPP4 activity had higher HbA1c, homeostatic model assessment of insulin resistance(HOMA-IR), triglyceride, low-density lipoprotein cholesterol(LDL-C), oxidized LDL, nitrotyrosine, 8-iso-PGF2a, interleukin-6 (IL-6), high-sensitivity C-reactive protein (hs-CRP), M6P-R, c-IMT compared with participants in the lowest quartile (all P < 0.001). DPP4 activities were associated positively with HbA1c, HOMA-IR, triglyceride, LDL-C, oxidized LDL, nitrotyrosine, 8-iso-PGF2a, IL-6, hs-CRP, M6P-R and c-IMT (all P < 0.05). The ORs for insulin resistance, dislipidemia, oxid...Continue Reading

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Citations

Jul 28, 2016·Journal of Proteomics·Pamella Araujo MalagrinoAlexandre Costa Pereira
Mar 28, 2017·Circulation Journal : Official Journal of the Japanese Circulation Society·Yanna LeiXianwu Cheng
Jul 16, 2017·Journal of the American Heart Association·Enbo ZhuXian Wu Cheng
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Jun 8, 2017·Cardiovascular Diabetology·Jing-Wei LiTian-Wen Han
Aug 15, 2021·Cardiovascular Diabetology·Nikolaos P E KadoglouVaia Lambadiari

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