PMID: 3321923Jan 1, 1987Paper

Increased plasma fibronectin concentrations in obesity: normalization during weight loss

Acta Medica Scandinavica
T AndersenC Gluud

Abstract

In 23 morbidly obese patients we investigated the influence of a large weight loss (30.6 kg, range 17.5-90.8) on the plasma fibronectin concentrations. Further, changes in plasma fibronectin were related to serum insulin levels and to liver biochemistry. Between the measurements patients had been treated with an intermittent very-low-calorie formula diet sufficient in respect to protein, minerals and vitamins. They were investigated in weight-stable states. Before weight reduction, 14 patients (61%, 95% confidence limits 39-80%) had elevated plasma fibronectin levels. Plasma fibronectin decreased (medians 1.22 and 0.59 mumol/l before and after weight loss, p less than 0.01) and was after weight loss within the normal range in 14 patients. The change in plasma fibronectin was unassociated with the magnitude of the weight loss as well as with the reduction of overweight. The resulting plasma fibronectin levels were also uncorrelated with the body weight and with the final degree of overweight. Serum insulin decreased (p less than 0.01) during the weight reduction and the change correlated (p less than 0.05) with the change in plasma fibronectin. Serum lactate dehydrogenase, which is associated with the degree of hepatic fatty cha...Continue Reading

References

Jan 1, 1979·Journal of Chronic Diseases·E A Lew, L Garfinkel
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Jul 1, 1983·The American Journal of Cardiology·M K Effron, D C Harrison

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Citations

Aug 22, 2017·Frontiers in Pharmacology·Flora A MiltonFrancisco de A R Neves
Dec 11, 2020·Journal of Thrombosis and Haemostasis : JTH·Nirav DhaneshaAnil K Chauhan
Jul 26, 2008·Archives of Gerontology and Geriatrics·L BizbizUNKNOWN EVA-group

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