Increased plasma HDL cholesterol levels and biliary cholesterol excretion in hamster by LCAT overexpression

FEBS Letters
Ai-Hong ZhangGeorge Liu

Abstract

Lecithin cholesterol acyltransferase (LCAT) is a key enzyme in the metabolism of high density lipoprotein (HDL), which has been found inversely correlated with atherosclerosis. Adenovirus mediated overexpression of human LCAT (hLCAT) in hamsters resulted in increased levels of plasma total cholesterol, HDL cholesterol, phospholipids and enlarged particle size of HDL. It also increased cholesterol and total bile acid concentrations in bile. Hepatic mRNA level of cholesterol 7alpha-hydroxylase increased 2.7-fold in hamsters. However, such effects were not observed in mice in a parallel experiment. This study suggests that overexpression of hLCAT in hamsters facilitated reverse cholesterol transport. Similar metabolic changes in humans might modify atherogenic risk.

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Citations

Aug 9, 2011·Journal of Cardiovascular Translational Research·Zhu ChenHeather H Zhou
Jul 8, 2010·The Journal of Pharmacology and Experimental Therapeutics·Xavier RoussetAlan T Remaley
May 9, 2012·Journal of Lipid Research·Sandra Kunnen, Miranda Van Eck
Dec 18, 2008·Canadian Journal of Physiology and Pharmacology·Hong-Bo XiaoYa-Ping Hu
Jun 6, 2006·Biochemical and Biophysical Research Communications·Wei HuangGeorge Liu
Aug 3, 2005·Circulation·G Kees HovinghJan Albert Kuivenhoven
Dec 9, 2015·The Journal of Biological Chemistry·Ruwanthi N GunawardaneMingyue Zhou
Jun 24, 2020·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Yihan ZhaoDazhuo Shi

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