Increased plasma human immunodeficiency virus type 1 burden following antigenic challenge with pneumococcal vaccine

The Journal of Infectious Diseases
B BrichacekM Stevenson

Abstract

Primary factors that influence virus burden during human immunodeficiency virus type 1 (HIV-1) disease progression remain a fundamental issue in pathogenesis. Because pneumococcal vaccine is routinely given to HIV-1-infected patients and replication of HIV-1 within CD4 T cells is dependent on the activation state of the cell, it was investigated whether the T cell activation that enhances the immune response to vaccines may also enhance HIV-1 replication. Vaccination of asymptomatic HIV-1-infected patients led to rapid and significant increases in virus burden in some patients. The magnitude of these increases correlated significantly with the extent of the antibody response to the vaccination. Thus, antigenic stimulation by vaccines designed to prevent secondary infections may promote HIV-1 replication in certain patients. These findings provide a window for examining HIV-1 pathogenesis and for determining the appropriate preventive measures against other diseases in HIV-1-infected persons.

Citations

Sep 5, 2002·Statistics in Medicine·H PutterF de Wolf
Nov 30, 2000·Current Infectious Disease Reports·S A Tasker, M R Wallace
Mar 10, 2006·Current Infectious Disease Reports·Todd D GleesonSybil A Tasker
Nov 30, 2000·Current Treatment Options in Cardiovascular Medicine·L J Goodman
Nov 14, 1998·Disease-a-month : DM·H W HorowitzG P Wormser
Dec 5, 1998·Veterinary Immunology and Immunopathology·J A KarlasA D Osterhaus
Dec 2, 1999·Vaccine·M C RousseauJ Delmont
Apr 13, 1999·Infectious Disease Clinics of North America·H Ahmad, E K Chapnick
Apr 17, 2001·Infectious Disease Clinics of North America·G A Poland
Mar 5, 2010·The New England Journal of Medicine·Neil FrenchCharles F Gilks
May 22, 2001·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·A D FineK Fukuda
Aug 7, 2001·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·C G WhitneyJ C Butler
Oct 1, 1997·Microbial Drug Resistance : MDR : Mechanisms, Epidemiology, and Disease·E N Janoff, J B Rubins
May 15, 2013·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Jessica A KahnKathleen E Squires
Dec 28, 2000·AIDS·P S SullivanUNKNOWN Adult and Adolescent Spectrum of HIV Disease Investigators
Aug 5, 2000·The Pediatric Infectious Disease Journal·M KellerS J Chang
May 15, 2007·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Laura E Jones, Alan S Perelson
Sep 13, 2006·BMC Infectious Diseases·Julius AtashiliAdaora A Adimora
Apr 17, 2002·European Journal of Pediatrics·Tandakha DieyeClaire-Michèle Farber
Sep 12, 2000·Lancet·G WattS Krishna
Dec 28, 1999·Proceedings of the National Academy of Sciences of the United States of America·N M FergusonR M Anderson
Oct 15, 1998·Proceedings of the National Academy of Sciences of the United States of America·S M WahlJ M Orenstein
Feb 19, 2002·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Sybil A TaskerEdward N Janoff
May 30, 1998·Proceedings of the National Academy of Sciences of the United States of America·Z GrossmanW E Paul
Jul 9, 2010·The Lancet Infectious Diseases·Kayvon Modjarrad, Sten H Vermund
May 25, 2012·The Journal of Investigative Dermatology·Monica CappellettiSilvia Della Bella
Jan 1, 1997·Tubercle and Lung Disease : the Official Journal of the International Union Against Tuberculosis and Lung Disease·G VanhamJ J Ellner
Jul 29, 1999·The Journal of Infection·D Churchill, J Weber

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