Increased plasma levels of advanced oxidation protein products (AOPP) as a marker for oxidative stress in patients with active ulcerative colitis

Clinics and Research in Hepatology and Gastroenterology
Hakan AlagozluSelahattin Unal

Abstract

After NADPH oxidase mediated radical formation, hypochloric acid (HOCl) is formed when Cl is used as a substrate by the myeloperoxidase enzyme. Myeloperoxidase is secreted from H2O2 activated leukocytes with polymorphic nuclei. The generation of HOCl also causes the formation of advanced oxidation protein products (AOPP) through damage to normal tissue and protein oxidation. AOPP has been identified as a marker of inflammation in many diseases. However, AOPP has not been investigated in ulcerative colitis. As a result of mucosal inflammation in ulcerative colitis, oxidative stress can occur. We aimed to determine whether plasma AOPP and oxidative stress markers are detectable in active ulcerative colitis. The patient group consisted of 59 patients who were diagnosed with ulcerative colitis in the clinic by histology and endoscopy. The patients were hospitalised and treated in the Gastroenterology Department of Gazi University Medical Facility. The 59 patients were separated into active and inactive groups according to the endoscopic activation index (EAI). Group I consisted of 33 active ulcerative colitis patients, Group II consisted of 26 inactive ulcerative colitis patients and Group III consisted of healthy control subjects....Continue Reading

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Citations

Aug 19, 2015·Clinical Biochemistry·Monica CurròDaniela Caccamo
Aug 30, 2014·Medicinal Research Reviews·Yunlong LeiCanhua Huang
Aug 26, 2014·Oxidative Medicine and Cellular Longevity·Kamila SyslováPetr Kačer
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Aug 28, 2021·Nanomaterials·Joana Costa AntunesHelena Prado Felgueiras

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