Abstract
Heat shock proteins (HSPs) have been regarded as cytoprotectants that protect brain cells during the progression of neurodegenerative diseases and from damage resulting from cerebral ischemia. In this study, we assessed the association between plasma HSP 70/27 levels and cognitive decline. Among participants in the community-based cohort study of dementia called the Gwangju Dementia and Mild Cognitive Impairment Study, subjects without cognitive impairment at baseline, who then either remained without impairment (non-conversion group), or suffered mild cognitive impairment (MCI) (conversion group) (non-conversion group, N = 36; conversion group, N = 30) were analyzed. After a five to six year follow-up period, comparison of the plasma HSP 70 and HSP 27 levels of the two groups revealed that only the plasma HSP 70 level was associated with a conversion to MCI after adjustments for age, gender, years of education, follow-up duration, APOE e4, hypertension, and diabetes (repeated measure analysis of variance: F = 7.59, p = 0.008). Furthermore, an increase in plasma HSP 70 level was associated with cognitive decline in language and executive function (linear mixed model: Korean Boston Naming Test, -0.426 [-0.781, -0.071], p = 0.019...Continue Reading
References
Jun 1, 1995·The Biochemical Journal·A Rossi, M G Santoro
Jan 1, 1994·Acta Neuropathologica·K RenkawekW W de Jong
Nov 1, 1993·Neurology·J C Morris
Jan 15, 1994·European Journal of Biochemistry·J Becker, E A Craig
Sep 23, 2000·Heart and Vessels·B H WrightA G Pockley
Feb 24, 2001·Annals of the New York Academy of Sciences·S J Charette, J Landry
Jan 18, 2002·Journal of Neurology, Neurosurgery, and Psychiatry·J H KramerH C Chui
Feb 28, 2002·Circulation·A Graham Pockley
Apr 5, 2002·Journal of Neuroscience Research·V CalabreseN G Abraham
May 29, 2002·Free Radical Biology & Medicine·D Allan Butterfield, Christopher M Lauderback
Jun 6, 2003·Current Opinion in Cell Biology·Yong Kook KangYong Mahn Han
Dec 20, 2003·Nature·Fred E Cohen, Jeffery W Kelly
Jan 24, 2004·Dementia and Geriatric Cognitive Disorders·Susanna TervoHilkka Soininen
Feb 14, 2004·The Journal of Biological Chemistry·Hideki ShimuraKenneth S Kosik
Feb 20, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Jordi MagranéHenry W Querfurth
Mar 24, 2004·Neurology·M IngelssonM C Irizarry
Aug 10, 2004·The Journal of Experimental Biology·Rona G GiffardMidori A Yenari
Nov 2, 2004·Nature Cell Biology·Dennis J Selkoe
Dec 22, 2004·Nature Reviews. Neuroscience·Paul J Muchowski, Jennifer L Wacker
Mar 17, 2005·Cellular and Molecular Life Sciences : CMLS·M P Mayer, B Bukau
Apr 13, 2005·Neurology·J N KellerW R Markesbery
Jul 29, 2005·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·T B FranklinR W Currie
Feb 10, 2006·Neurobiology of Disease·D Allan ButterfieldWilliam R Markesbery
Sep 16, 2006·The Journal of Biological Chemistry·Christopher G EvansJason E Gestwicki
Jul 28, 2007·Annals of the New York Academy of Sciences·Ian R Brown
Dec 7, 2007·Journal of Neuroscience Research·Cecilia BjörkdahlJin-Jing Pei
Mar 8, 2008·Neurobiology of Disease·Tanea ReedD Allan Butterfield
Apr 9, 2008·Neuroscience Letters·Kang Soo LeeChang Hyung Hong
Sep 25, 2009·Journal of Bioenergetics and Biomembranes·Rukhsana Sultana, D Allan Butterfield
Feb 23, 2010·Current Pharmaceutical Biotechnology·Shigeki ArawakaTakeo Kato
Apr 7, 2010·Brain Research·Fabio Di DomenicoD Allan Butterfield
Mar 30, 2011·BMC Immunology·Rose NjeminiTony Mets
Aug 5, 2011·Psychoneuroendocrinology·Eosu KimByoung Hoon Oh
Aug 31, 2012·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·B W WangG Y R Hsiung
Oct 11, 2012·AIDS Research and Treatment·O Olajumoke OshinaikeA Mustapha Danesi
Nov 14, 2012·The Journal of Clinical Psychiatry·Sang Joon SonChang Hyung Hong
Citations
Dec 8, 2015·Cell Stress & Chaperones·Arash Aghajani NargesiManouchehr Nakhjavani
May 4, 2016·Annals of Laboratory Medicine·Matthias ZimmermannThomas Mueller
May 11, 2016·Journal of Alzheimer's Disease : JAD·Hyun Woong RohSang Joon Son
Jul 10, 2018·Oncotarget·Ana Paula Trussardi FayhMauricio Krause
Dec 26, 2018·Journal of Alzheimer's Disease : JAD·Antonella Marino GammazzaRoberto Monastero
Jan 11, 2021·Brain Research·Lauren V OwensEdward T Parkin
May 29, 2021·Journal of Immunology Research·Zhanglong PengMarie-Francoise Doursout