Increased plasma levels of heat shock protein 70 associated with subsequent clinical conversion to mild cognitive impairment in cognitively healthy elderly

PloS One
Sang Joon SonByoung Hoon Oh

Abstract

Heat shock proteins (HSPs) have been regarded as cytoprotectants that protect brain cells during the progression of neurodegenerative diseases and from damage resulting from cerebral ischemia. In this study, we assessed the association between plasma HSP 70/27 levels and cognitive decline. Among participants in the community-based cohort study of dementia called the Gwangju Dementia and Mild Cognitive Impairment Study, subjects without cognitive impairment at baseline, who then either remained without impairment (non-conversion group), or suffered mild cognitive impairment (MCI) (conversion group) (non-conversion group, N = 36; conversion group, N = 30) were analyzed. After a five to six year follow-up period, comparison of the plasma HSP 70 and HSP 27 levels of the two groups revealed that only the plasma HSP 70 level was associated with a conversion to MCI after adjustments for age, gender, years of education, follow-up duration, APOE e4, hypertension, and diabetes (repeated measure analysis of variance: F = 7.59, p = 0.008). Furthermore, an increase in plasma HSP 70 level was associated with cognitive decline in language and executive function (linear mixed model: Korean Boston Naming Test, -0.426 [-0.781, -0.071], p = 0.019...Continue Reading

References

Jan 15, 1994·European Journal of Biochemistry·J Becker, E A Craig
Feb 24, 2001·Annals of the New York Academy of Sciences·S J Charette, J Landry
Jan 18, 2002·Journal of Neurology, Neurosurgery, and Psychiatry·J H KramerH C Chui
Feb 28, 2002·Circulation·A Graham Pockley
Jun 6, 2003·Current Opinion in Cell Biology·Yong Kook KangYong Mahn Han
Dec 20, 2003·Nature·Fred E Cohen, Jeffery W Kelly
Feb 20, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Jordi MagranéHenry W Querfurth
Aug 10, 2004·The Journal of Experimental Biology·Rona G GiffardMidori A Yenari
Dec 22, 2004·Nature Reviews. Neuroscience·Paul J Muchowski, Jennifer L Wacker
Mar 17, 2005·Cellular and Molecular Life Sciences : CMLS·M P Mayer, B Bukau
Jul 29, 2005·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·T B FranklinR W Currie
Sep 16, 2006·The Journal of Biological Chemistry·Christopher G EvansJason E Gestwicki
Jul 28, 2007·Annals of the New York Academy of Sciences·Ian R Brown
Sep 25, 2009·Journal of Bioenergetics and Biomembranes·Rukhsana Sultana, D Allan Butterfield
Mar 30, 2011·BMC Immunology·Rose NjeminiTony Mets
Aug 31, 2012·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·B W WangG Y R Hsiung

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Citations

May 29, 2021·Journal of Immunology Research·Zhanglong PengMarie-Francoise Doursout

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Methods Mentioned

BETA
enzyme-linked immunosorbent assay
ubiquitination

Software Mentioned

SPSS
GDEMCIS

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