Increased plasma levels of high mobility group box 1 in patients with acute liver failure

European Surgical Research. Europäische Chirurgische Forschung. Recherches Chirurgicales Européennes
G OshimaY Kitagawa

Abstract

High-mobility group box 1 (HMGB1) is a monocyte-derived late-acting inflammatory mediator, which is released in conditions such as shock, tissue injury and endotoxin-induced lethality. In this study, we determined the plasma and hepatic tissue levels of HMGB1 in patients with acute liver failure (ALF). We determined the plasma levels of HMGB1 and aspartate aminotransferase (AST) in 7 healthy volunteers (HVs), 40 patients with liver cirrhosis (LC), 37 patients with chronic hepatitis (CH), 18 patients with severe acute hepatitis (AH), and 14 patients with fulminant hepatitis (FH). The 14 patients with FH were divided into two subgroups depending upon the history of plasma exchange (PE) before their plasma sample collection. The hepatic levels of HMGB1 were measured in tissue samples from 3 patients with FH who underwent living-donor liver transplantation and from 3 healthy living donors. Hepatic tissue samples were also subjected to immunohistochemical examination for HMGB1. The plasma levels of HMGB1 (ng/ml) were higher in patients with liver diseases, especially in FH patients with no history of PE, than in HVs (0.3 ± 0.3 in HVs, 4.0 ± 2.0 in LC, 5.2 ± 2.6 in CH, 8.6 ± 4.8 in severe AH, 7.8 ± 2.7 in FH with a history of PE, and...Continue Reading

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Citations

Jul 11, 2014·Molecular Aspects of Medicine·Rui KangDaolin Tang
Dec 17, 2014·The Journal of Surgical Research·Masayuki TanakaYuko Kitagawa
Jul 1, 2016·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Tea Lund LaursenThomas Damgaard Sandahl
Mar 13, 2018·The International Journal of Artificial Organs·Ryusuke AmemiyaYuko Kitagawa
Jun 16, 2017·Gene Regulation and Systems Biology·Lisl Km ShodaBrett A Howell
Dec 5, 2017·European Journal of Gastroenterology & Hepatology·Tao ZhangWei Jiang
Jan 18, 2014·European Surgical Research. Europäische Chirurgische Forschung. Recherches Chirurgicales Européennes·R NishiyamaY Kitagawa
Dec 3, 2016·Molecular Medicine·Ruben ZamoraRobert H Squires
Nov 27, 2018·Hepatology International·Runkuan Yang, Tor Inge Tonnesseen
Jun 14, 2014·Expert Review of Molecular Diagnostics·Anna AlisiLaura Stronati
Feb 27, 2018·Journal of Agricultural and Food Chemistry·Qingling CuiWei Xiao

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