Abstract
Thrombocytopenia in malaria involves platelet destruction and consumption; however, the cellular response underlying this phenomenon has still not been elucidated. To find associations between platelet indices and unbalanced Th1/Th2/Th17 cytokines as a response to thrombocytopenia in Plasmodium vivax infected (Pv-MAL) patients. Platelet counts and quantification of Th1/Th2/Th17 cytokine levels were compared in 77 patients with uncomplicated P. vivax malaria and 37 healthy donors from the same area (endemic control group - ENCG). Thrombocytopenia was the main manifestation in 55 patients, but was not associated with parasitaemia. The Pv-MAL patients showed increases in the mean platelet volume (MPV), which may be consistent with larger or megaplatelets. Contrary to the findings regarding the endemic control group, MPV and platelet distribution width (PDW) did not show an inverse correlation, due the increase in the heterogeneity of platelet width. In addition, the Pv-MAL patients presented increased IL-1β and reduced IL-12p70 and IL-2 serum concentrations. Furthermore, the reduction of these cytokines was associated with PDW values. Our data demonstrate that an increase in MPV and the association between reductions of IL-2 and I...Continue Reading
References
Aug 16, 2000·Baillière's Best Practice & Research. Clinical Haematology·S N Wickramasinghe, S H Abdalla
Jan 29, 2003·The Journal of Infectious Diseases·Georges E GrauMalcolm E Molyneux
Jul 2, 2003·Annals of Tropical Medicine and Parasitology·J-W ParkJ-Y Seoh
Feb 26, 2004·Thrombosis and Haemostasis·Georgios KaranikasKurt Kletter
Jan 15, 2010·Malaria Journal·Bruno B AndradeManoel Barral-Netto
Jan 22, 2010·Cellular and Molecular Life Sciences : CMLS·Dermot Cox, Sam McConkey
Jul 14, 2010·Seminars in Hematology·Amy E Geddis
Oct 20, 2010·British Journal of Haematology·Quirijn de MastAndre J van der Ven
Aug 26, 2011·Platelets·Gajanand Singh TanwarDhanpat Kumar Kochar
Feb 14, 2012·Annals of Tropical Medicine and Parasitology·K SaravuB A Shastry
Oct 25, 2012·Clinical Chemistry and Laboratory Medicine : CCLM·Giuseppe Lippi, Emmanuel J Favaloro
Dec 29, 2013·Malaria Journal·Fábio A Leal-SantosCor J F Fontes
Aug 17, 2014·Malaria Journal·Afsheen RazaMohammad A Beg
Aug 30, 2014·The Journal of Infectious Diseases·Daniel A LampahRic N Price
Dec 10, 2014·Malaria Journal·Bilal Ahmad RahimiWatcharee Chokejindachai
Apr 25, 2015·BMC Medicine·Josh HansonNicholas P J Day
Sep 2, 2016·Malaria Journal·Yury Oliveira ChavesPaulo Afonso Nogueira
Feb 27, 2017·Journal of Leukocyte Biology·Gerhard Müller-NewenPatrick Ziegler
Feb 13, 2018·Infectious Diseases of Poverty·Cho Naing, Maxine A Whittaker
Oct 16, 2018·Growth Factors·Kira Behrens, Warren S Alexander
Dec 12, 2018·The American Journal of Tropical Medicine and Hygiene·Elisa RubioCliment Casals-Pascual
Apr 11, 2019·Pathogens and Global Health·Pranjal GuptaKavitha Saravu