Increased platelet volume in a general population with prehypertension: a cross-sectional study of 80 545 participants from China

Hypertension Research : Official Journal of the Japanese Society of Hypertension
Xia CaoZhiheng Chen

Abstract

Mean platelet volume (MPV), an indicator of platelet activation, has been shown to be elevated in patients with hypertension. However, data available on the association between MPV level and prehypertension are limited. Prehypertension is also associated with an increase in cardiovascular morbidity and mortality. A cross-sectional study was performed among 80 545 standardized medical checkup participants <18 years in age without hypertension or diabetes in China between April 2009 and May 2010. Blood pressure was categorized as prehypertensive (systolic blood pressure, 120-140 mm Hg and/or diastolic blood pressure, 80 to 90 mm Hg, n= 36 586) and normotensive (systolic blood pressure, < 120 mm Hg and diastolic blood pressure, <80 mm Hg, n=43 959). Mean systolic blood pressure and the prevalence of prehypertension increased significantly with increasing MPV. After adjusting for demographics, body mass index, smoking and serum cholesterol, the odds ratio for prehypertension, when comparing the highest category of MPV (>12.0 fl) with the lowest category (<10.1 fl), was 1.08 (95% confidence interval, 1.02-1.13; P for trend=0.014). This association persisted in separate analysis among men but not among women. In nonparametric models,...Continue Reading

References

Nov 1, 1993·Circulation·D PerloffB Z Morgenstern
Oct 17, 2002·JAMA : the Journal of the American Medical Association·Paul K WheltonUNKNOWN National High Blood Pressure Education Program Coordinating Committee
Aug 29, 2003·Platelets·I Anita JagroopDimitri P Mikhailidis
Dec 6, 2003·Hypertension·Aram V ChobanianUNKNOWN National High Blood Pressure Education Program Coordinating Committee
Feb 21, 2004·Stroke; a Journal of Cerebral Circulation·Philip BathUNKNOWN PROGRESS Collaborative Group
Mar 15, 2005·Platelets·N PapanasG Lakasas
May 21, 2005·Annals of Medicine·Sunil K NadarGregory Y H Lip
Dec 3, 2005·The Journal of Clinical Investigation·Meinrad GawazAndreas E May
Apr 11, 2006·Journal of Perinatal Medicine·Juan PiazzeMaurizio Anceschi
Oct 19, 2006·Thrombosis Research·Christopher J Boos, Gregory Y H Lip
Jun 19, 2007·Journal of Thrombosis and Thrombolysis·Christopher J BoosGregory Y H Lip
Mar 21, 2009·Journal of Hypertension·Dongfeng GuJiang He
Jul 1, 2009·Circulation Journal : Official Journal of the Japanese Circulation Society·Mingzhi ZhangYonghong Zhang
Nov 26, 2009·Blood Pressure·Serkan OrduIsmail Erden
Dec 5, 2009·Blood Pressure·Amanda Elisabeth KielyMadan Mohan Kwatra
Apr 24, 2010·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Anna WasilewskaWalentyna Zoch-Zwierz
Jun 24, 2010·Clinical Hemorheology and Microcirculation·Ercan VarolMehmet Ozaydin
Apr 1, 2011·European Journal of Cardiovascular Prevention and Rehabilitation : Official Journal of the European Society of Cardiology, Working Groups on Epidemiology & Prevention and Cardiac Rehabilitation and Exercise Physiology·Aline B NeryMaria Luiza G Rosa
Jul 23, 2011·Clinical and Experimental Hypertension : CHE·Cagdas YukselHalil Yaman

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Citations

Jan 19, 2016·European Journal of Internal Medicine·Nakarin SansanayudhAmmarin Thakkinstian
Feb 4, 2014·Medical Hypotheses·Ozgur YorbikOmer Ozcan
Sep 24, 2013·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·Giuseppe LippiGianfranco Cervellin
Dec 15, 2016·Turkish Journal of Medical Sciences·Aslı Araz GüngörEray Atalay
May 15, 2021·Biomarkers in Medicine·Tingwei LiYaguang Fan

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