PMID: 8927036Dec 6, 1995

Increased potency of vanadium using organic ligands

Molecular and Cellular Biochemistry
J H McNeillC Orvig

Abstract

The in vivo glucose lowering effect of orally administered inorganic vanadium compounds in diabetes was first reported in our laboratory in 1985. While both vanadate and vanadyl forms of vanadium are orally active, they are still not well absorbed. We have synthesized several organic vanadium compounds and one compound, bis(maltolato)oxovanadium(lV) or BMOV, has been extensively investigated. BMOV proved effective in lowering plasma glucose and lipids in STZ-diabetic rats when administered in drinking water over a 25 week period. The maintenance dose (0.18 mmol/kg/day) was approximately 50% of that required for vanadyl sulfate (VS). Secondary complications of diabetes were prevented by BMOV and no marked toxicity was noted. Oral gavage of STZ-diabetic rats with BMOV also reduced blood glucose levels. The ED50 for BMOV was 0.5 mmol/kg, while for VS the estimated ED50 was 0.9 mmol/kg. BMOV was also effective by the intraperitoneal route in STZ-diabetic rats. The ED50 was 0.08 mmol/kg compared to 0.22 mmol/kg for VS. Some animals treated p.o. or i.p. remained euglycemic for up to 14 weeks. An i.v. infusion of BMOV of 0.05 mmol/kg over a 30 min period reduced plasma glucose levels by 50% while VS was not effective.

References

Apr 17, 1992·Journal of Medicinal Chemistry·J H McNeillC Orvig
May 1, 1988·Endocrinology·W C DuckworthD E Peavy
Nov 1, 1987·Hypertension·I S HwangG M Reaven
Nov 1, 1969·The Journal of Clinical Investigation·A JunodA E Renold
Jan 1, 1984·Annual Review of Pharmacology and Toxicology·B R Nechay
Feb 1, 1994·Pharmacology & Toxicology·S DaiJ H McNeill
May 1, 1993·Diabetes Research and Clinical Practice·M C CamJ H McNeill
Mar 1, 1993·Canadian Journal of Physiology and Pharmacology·V G YuenJ H McNeill

Citations

Jun 1, 2006·Naunyn-Schmiedeberg's Archives of Pharmacology·Dhvanit I Shah, Manjeet Singh
Feb 20, 1998·Physiology & Behavior·D J SanchezJ L Domingo
Dec 16, 1998·Trends in Pharmacological Sciences·A MorinvilleA Shaver
Feb 27, 1998·Journal of the American College of Nutrition·S VermaJ H McNeill
Oct 28, 1998·Environmental Health Perspectives·C M Krejsa, G L Schieven
Mar 4, 2005·Treatments in Endocrinology·Dominique Bonnefont-Rousselot
Feb 23, 2013·Heart Failure Reviews·Tod A ClarkGrant N Pierce
Jul 18, 2006·Biochemical and Biophysical Research Communications·David L BrautiganHong Wang
Sep 26, 2006·Canadian Journal of Physiology and Pharmacology·Daniel A BarrioSusana B Etcheverry
Apr 24, 2008·Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine·Xueqin MaoYujing Tang
May 1, 2009·Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine·Ming LiDebbie C Crans
Jul 10, 2010·Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine·Liping LuXueqi Fu
Jan 31, 2006·Vascular Pharmacology·Dhvanit I Shah, Manjeet Singh
Aug 16, 2012·Journal of Dietary Supplements·Catherine UlbrichtSara Zhou
Jun 1, 2016·Applied Biochemistry and Biotechnology·Pingzhe JiangMinggang Li
Nov 10, 2001·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·T KawanoE Miyamoto
Mar 11, 2018·Biological Trace Element Research·Deepika TripathiRavi Prakash Pal
Dec 1, 1996·Critical Reviews in Biochemistry and Molecular Biology·N SekarY Shechter
Oct 18, 2012·Metallomics : Integrated Biometal Science·Ignacio E LeónSusana B Etcheverry
Mar 14, 2019·Applied Biochemistry and Biotechnology·Minoli Anuththara GunasingheSang Moo Kim

Related Concepts

Metazoa
Diabetes Mellitus
Vanadium Compounds

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Synthetic Genetic Array Analysis

Synthetic genetic arrays allow the systematic examination of genetic interactions. Here is the latest research focusing on synthetic genetic arrays and their analyses.

Neural Activity: Imaging

Imaging of neural activity in vivo has developed rapidly recently with the advancement of fluorescence microscopy, including new applications using miniaturized microscopes (miniscopes). This feed follows the progress in this growing field.

Computational Methods for Protein Structures

Computational methods employing machine learning algorithms are powerful tools that can be used to predict the effect of mutations on protein structure. This is important in neurodegenerative disorders, where some mutations can cause the formation of toxic protein aggregations. This feed follows the latests insights into the relationships between mutation and protein structure leading to better understanding of disease.

Congenital Hyperinsulinism

Congenital hyperinsulinism is caused by genetic mutations resulting in excess insulin secretion from beta cells of the pancreas. Here is the latest research.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Epigenetic Memory

Epigenetic memory refers to the heritable genetic changes that are not explained by the DNA sequence. Find the latest research on epigenetic memory here.

Cell Atlas of the Human Eye

Constructing a cell atlas of the human eye will require transcriptomic and histologic analysis over the lifespan. This understanding will aid in the study of development and disease. Find the latest research pertaining to the Cell Atlas of the Human Eye here.

Femoral Neoplasms

Femoral Neoplasms are bone tumors that arise in the femur. Discover the latest research on femoral neoplasms here.