Increased prebeta-high density lipoprotein, apolipoprotein AI, and phospholipid in mice expressing the human phospholipid transfer protein and human apolipoprotein AI transgenes

The Journal of Clinical Investigation
X C JiangAlan R Tall

Abstract

Human plasma phospholipid transfer protein (PLTP) circulates bound to high density lipoprotein (HDL) and mediates both net transfer and exchange of phospholipids between different lipoproteins. However, its overall function in lipoprotein metabolism is unknown. To assess the effects of increased plasma levels of PLTP, human PLTP transgenic mice were established using the human PLTP gene driven by its natural promoter. One line of PLTP transgenic mice with moderate expression of PLTP mRNA and protein was obtained. The order of human PLTP mRNA expression in tissues was: liver, kidney, brain, small intestine > lung > spleen > heart, adipose tissue. Western blotting using a human PLTP monoclonal antibody revealed authentic human PLTP (Mr 80 kD) in plasma. Plasma PLTP activity was increased by 29% in PLTP transgenic mice. However, plasma lipoprotein analysis, comparing PLTP transgenic mice to control littermates, revealed no significant changes in the plasma lipoprotein lipids or apolipoproteins. Since previous studies have shown that human cholesteryl ester transfer protein and lecithin:cholesterol acyltransferase only function optimally in human apoAI transgenic mice, the human PLTP transgenic mice were cross-bred with human apoAI...Continue Reading

References

Mar 1, 1991·Arteriosclerosis and Thrombosis : a Journal of Vascular Biology·M A ClayP J Barter
Mar 1, 1993·Arteriosclerosis and Thrombosis : a Journal of Vascular Biology·Y HuangG Assmann

❮ Previous
Next ❯

Citations

Sep 28, 2001·Biochemical and Biophysical Research Communications·A Y Tu, J J Albers
Dec 21, 2000·Current Atherosclerosis Reports·M A KawashiriD J Rader
Mar 3, 2011·Current Atherosclerosis Reports·Amirfarbod YazdanyarXian-Cheng Jiang
Sep 6, 2003·The American Journal of Cardiology·Daniel J Rader
May 23, 1998·Biochimica Et Biophysica Acta·J HuuskonenC Ehnholm
Jun 24, 1998·Biochimica Et Biophysica Acta·S Yokoyama
Jun 11, 2002·Biochemical and Biophysical Research Communications·Charlotte A BurtonCarl P Sparrow
Mar 20, 2001·Atherosclerosis·J HuuskonenC Ehnholm
Mar 13, 2002·Atherosclerosis·Dmitri Sviridov, Paul Nestel
Aug 7, 1998·Atherosclerosis·A von Eckardstein, G Assmann
Sep 17, 1999·Atherosclerosis·K A RyeP J Barter
Oct 27, 1998·Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology·V Guyard-DangremontL Lagrost
Apr 6, 2001·Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology·S JaariC Ehnholm
Sep 22, 2001·Biochimica Et Biophysica Acta·P J PussinenM Jauhiainen
Dec 9, 2008·Nature Genetics·Sekar KathiresanL Adrienne Cupples
Jun 30, 1998·Current Opinion in Lipidology·L LagrostP Gambert
Nov 13, 1998·Current Opinion in Lipidology·M NavabA M Fogelman
Apr 29, 2000·Current Opinion in Lipidology·A D Kalopissis, J Chambaz
Jul 6, 2000·Current Opinion in Lipidology·J Huuskonen, C Ehnholm
Nov 22, 2000·Current Opinion in Lipidology·A von Eckardstein, G Assmann
May 29, 2004·Current Opinion in Lipidology·John J Albers, Marian C Cheung
May 18, 2011·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Sarah J EhlersJi-Young Lee
Dec 5, 2006·The Journal of Clinical Investigation·Daniel J Rader
Jul 7, 2007·BMC Developmental Biology·Laetitia MagnolYann Hérault
Aug 18, 2012·Nutrition & Metabolism·Xian-Cheng JiangMahmood M Hussain
Jul 16, 2011·Journal of Lipid Research·Elisabeth A RosenthalGail P Jarvik
Nov 3, 2010·Journal of Lipid Research·Christopher T JohansenRobert A Hegele

❮ Previous
Next ❯

Related Concepts

Related Feeds

ApoE, Lipids & Cholesterol

Serum cholesterol, triglycerides, apolipoprotein B (APOB)-containing lipoproteins (very low-density lipoprotein (VLDL), immediate-density lipoprotein (IDL), and low-density lipoprotein (LDL), lipoprotein A (LPA)) and the total cholesterol/high-density lipoprotein (HDL) cholesterol ratio are all connected in diseases. Here is the latest research.