Increased presynaptic regulation of dopamine neurotransmission in the nucleus accumbens core following chronic ethanol self-administration in female macaques

Psychopharmacology
Cody A SicilianoSara R Jones

Abstract

Hypofunction of striatal dopamine neurotransmission, or hypodopaminergia, is a consequence of excessive ethanol use and is hypothesized to be a critical component of alcoholism, driving alcohol intake in an attempt to restore dopamine levels; however, the neurochemical mechanisms involved in these dopaminergic deficiencies are not fully understood. Here we examined the specific dopaminergic adaptations that produce hypodopaminergia and contribute to alcohol use disorders using direct, sub-second measurements of dopamine signaling in nonhuman primates following chronic ethanol self-administration. Female rhesus macaques completed 1 year of daily (22 h/day) ethanol self-administration. Subsequently, fast-scan cyclic voltammetry was used in nucleus accumbens core brain slices to determine alterations in dopamine terminal function, including release and uptake kinetics, and sensitivity to quinpirole (D2/D3 dopamine receptor agonist) and U50,488 (kappa opioid receptor agonist) induced inhibition of dopamine release. Ethanol drinking greatly increased uptake rates, which were positively correlated with lifetime ethanol intake. Furthermore, the sensitivity of dopamine D2/D3 autoreceptors and kappa opioid receptors, which both act as n...Continue Reading

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Citations

Jul 19, 2016·Alcohol·Cody A SicilianoSara R Jones
Apr 10, 2017·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Giovanni AddoloratoDaniela Di Giuda
Jan 4, 2017·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Anna MurphyRebecca Elliott
Oct 21, 2017·Psychopharmacology·Daicia C AllenKathleen A Grant
Jun 27, 2018·Alcoholism, Clinical and Experimental Research·Nancy J AlexanderBrian A McCool
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Jan 17, 2021·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Armando G SalinasDavid M Lovinger
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Mar 3, 2020·Brain Research·Anushree N Karkhanis, Ream Al-Hasani
May 28, 2021·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Brianna E GeorgeSara R Jones
Oct 26, 2021·Alcohol and Alcoholism : International Journal of the Medical Council on Alcoholism·Abdelkader Dahchour, Roberta J Ward

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